化合物 SU5402|T6996|TargetMol

价格	￥221	￥493	￥663
包装	1mg	5mg	10mg

最小起订量	1mg
发货地	上海
更新日期	2024-09-29

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产品详情

中文名称:化合物 SU5402	英文名称:SU 5402
CAS:215543-92-3	品牌: TargetMol
产地: 美国	保存条件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
纯度规格: 99.64%	产品类别: 抑制剂
货号: T6996

Product Introduction

Bioactivity

Name	SU 5402
Description	SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.
Cell Research	Tumor cell lines used in the in vitro growth are cultured in media at 37°C in 5–10% CO2. SU5416 is serially diluted in media containing DMSO (<0.5%) and added to cultures of tumor cells 1 day after the initiation of culture. Cell growth is measured after 96 h using the sulforhodamine B method. IC50s are calculated by curve fitting using four-parameter analysis.(Only for Reference)
Kinase Assay	FGF-R1 and Flk-1/KDR kinase assays.: The catalytic portion of FGF-R1 and Flk-1/KDR are expressed as GST fusion proteins following infection of Spodoptera frugiperda (sf9) cells with engineered baculoviruses. GST-FGFR1 and GST-Flk1 are purified to homogeneity from infected sf9 cell lysates by glutathione sepharose chromatography. The assays are performed in 96-well microtiter plates that had been coated overnight with 2.0 μg of a polyGlu-Tyr peptide (4:1) in 0.1 mL of PBS per well. The purified kinases are diluted in kinase assay buffer (100 mM Hepes pH 7.5, 100 mM NaCl, and 0.1 mM sodium orthovanadate) and added to all test wells at 5 ng of GST fusion protein per 0.05 mL volume buffer. Test compounds are diluted in 4% DMSO and added to test wells (0.025 mL/well). The kinase reaction is initiated by the addition of 0.025 mL of 40 μM ATP/40 mM MnCl2, and plates are shaken for 10 min before stopping the reactions with the addition of 0.025 mL of 0.5 M EDTA. The final ATP concentration was 10 μM, which is twice the experimentally determined Km value for ATP. Negative control wells receive MnCl2 alone without ATP. The plates are washed three times with 10 mM Tris pH 7.4, 150 mM NaCl, and 0.05% Tween-20 (TBST). Rabbit polyclonal anti-phosphotyrosine antiserum is added to the wells at a 1:10000 dilution in TBST for 1 h. The plates are then washed three times with TBST. Goat anti-rabbit antiserum conjugated with horseradish peroxidase was then added to all wells for 1 h. The plates are washed three times with TBST, and the peroxidase reaction is detected with the addition of 2,2‘-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS). The color readout of the assay is allowed to develop for 20?30 min and read on a Dynatech MR5000 ELISA plate reader using a 410 nM test filter.
In vitro	SU5402分别以IC50为0.05μM、2.80μM、28.4μM抑制VEGF-、FGF-、PDGF-依赖的细胞增殖。[1] 在HUVECs中，SU5416以IC50为0.04μM的剂量依赖性选择性抑制VEGF驱动的细胞增殖。[2] 在鼻咽上皮细胞中，SU5402抑制LMP1介导的有氧糖酵解、细胞转化、细胞迁移和侵入。[3] 在小鼠C3H10T1/2细胞中，SU 5402减少了FGF23对细胞分化的影响。[4]
In vivo	在小鼠中，SU5416（25 mg/kg，i.p.）通过抑制与肿瘤生长相关的血管生成过程，抑制了一系列肿瘤细胞系的皮下生长。[2]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 29.6 mg/mL (100 mM)
Keywords	VEGFR \| SU 5402 \| inhibit \| Inhibitor \| Fibroblast growth factor receptor \| FGFR \| Platelet-derived growth factor receptor \| PDGFR \| SU-5402 \| Vascular endothelial growth factor receptor
Inhibitors Related	Imatinib \| Amlexanox \| Ribociclib \| Formononetin \| Axitinib \| Lenvatinib mesylate \| Ferulic Acid \| Regorafenib \| Pazopanib \| Nintedanib \| Sorafenib \| Regorafenib monohydrate
Related Compound Libraries	Inhibitor Library \| Bioactive Compound Library \| Anti-Cancer Active Compound Library \| Anti-Cancer Compound Library \| Bioactive Compounds Library Max \| Kinase Inhibitor Library \| Stem Cell Differentiation Compound Library \| Membrane Protein-targeted Compound Library \| Tyrosine Kinase Inhibitor Library \| Reprogramming Compound Library

关键字： SU5402|TargetMol

公司简介

TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol?品牌的客户群分布于40多个国家和地区，已发展成为全球知名的化合物库和小分子化合物研究供应商。 TargetMol?可提供160多种满足不同需求的化合物库，以及多种类型的生化试剂产品，包括12000多种抑制剂、16000多种天然产物和各类多肽、抗体、生命科学试剂盒等，此外，我们还建设有CADD（计算机辅助药物设计）研究中心、药理实验室、药化合成平台三大技术中心，全方位满足客户的定制需求。凭借我们优质的产品和服务、快速高效的全球供应链和专业的技术支持，我们将有效帮助您缩短研发周期，取得更成功的结果。

成立日期	2013-04-18 （12年）	注册资本	566.265100万人民币
员工人数	100-500人	年营业额	￥ 1亿以上
主营行业	天然产物,生化试剂,分子生物学,分子砌块,生物技术服务	经营模式	贸易,工厂,试剂,定制,服务

TargetMol中国（陶术生物）

VIP 3年

公司成立：12年
注册资本：566.265100万人民币
企业类型：有限责任公司(自然人投资或控股)
主营产品：小分子抑制剂、药物筛选化合物库、药物筛选等
公司地址：静安区江场三路238号8楼

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化合物 SU5402|T6996|TargetMol相关厂家报价

产品名称	价格		公司名称	报价日期
多靶点受体酪氨酸激酶抑制剂(SU 5402)	询价	VIP5年	上海泽叶生物科技有限公司	2024-11-22
SU-5402	询价		南京百鑫德诺生物科技有限公司	2024-09-26
aladdin 阿拉丁 S276590 SU-5402 215543-92-3 ≥98%	￥514.90	VIP1年	上海阿拉丁生化科技股份有限公司	2024-08-16

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