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抑制剂描述:
产品名称:FH535
产品别名:FH 535; FH-535
英文别名:FH 535;FH-535
靶点:Wnt/β-catenin;PPARγ;PPARδ
CAS:108409-83-2
纯度:98%
外观:Yellow solid
保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
描述:
FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling.
溶解性:DMSO :72mg/ml(199.34 mM)
体外研究:
FH535 antagonizes β-Catenin/Tcf–mediated transcription, and inhibits recruitment of the coactivators GRIP1 and β-catenin to PPARδ and PPARγ. FH535 shows selective anti-proliferation effect on some cancer cells expressing high or active Wnt/β-catenin pathway. FH535 increases cigarette smoke condensate cytotoxicity, and causes changes in β-catenin and EGR-1 signaling. FH535 has potential therapeutic value in treatment of liver cancer by targeting liver cancer stem cells and hepatocellular carcinoma cell lines.
体内研究:FH535 (25 mg/kg, i.p.) exhibits an anti-tumor effect on pancreatic cancer xenografts in mice. FH535 also represses angiogenesis in pancreatic cancer xenografts.
产品信息订购:
abs810355
FH535
5mg
440
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