Estradiol valerate:Effect,Side effects,

Estradiol valerate is used in hormone therapy for menopausal symptoms and low estrogen levels, hormone therapy for transgender people, and in hormonal birth control.It is also used in the treatment of prostate cancer.

Effect

Regardless of the route of administration, estradiol valerate behaves as a prodrug of estradiol via cleavage by esterases into estradiol and the natural fatty acid valeric acid.This cleavage occurs not only in the liver, but also in the blood and in tissues, and the hydrolysis of estradiol valerate into estradiol and valeric acid is complete regardless of whether the medication is administered orally or parenterally.

High levels of circulating estradiol are found after an intravenous injection of estradiol valerate, and this indicates very rapid cleavage of the medication upon entering circulation

Side effects

Serious Side Effects

Vaginal bleeding or spotting.

Shortness of breath, cold sweat, and bluish-colored skin.

Sudden or severe headache, problems with vision, speech, or walking.

Pain in your lower leg (calf).

Swelling in your hands, ankles, or feet.

Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Blistering, peeling, red skin rash.

Breast changes or lumps.

Chest pain, or coughing up blood.

Dark-colored urine or pale stools, yellowing of your skin or the whites of your eyes.

Nausea, vomiting, loss of appetite, pain in your upper stomach.

Numbness or weakness in your arm or leg, or on one side of your body.

Less Serious Side Effects

Hair loss, increased hair growth, or skin changes.

Joint pain.

Mood changes or depression.

Weight gain or loss.

Problems or discomfort when wearing contact lenses.

Breast pain or tenderness, discharge from your nipples.

Vaginal itching or discharge.