Sodium Salicylate vs Aspirin
Jan 20,2022
Sodium salicylate is a metabolite of acetylsalicylic acid (sc-217570), and functions by inhibiting NF κ B and reduces oxidative stress. The agent has the ability to protect against neurotoxicity induced by glutamate in rat studies. Along with aspirin (sc-202471), sodium salicylate is an anti-inflammatory compound that binds to and inhibits IKK β. Sodium salicylate has been shown to reduce ATP binding in vitro and in vivo. Sodium Salicylate is an inhibitor of c-Jun and Cox-2 and an activator of p38.
Sodium salicylate is the “other” nonprescription salicylate. Its characteristics are similar to those of aspirin with one major exception: sodium salicylate is not acetylated. As such, it does not have a two-compartment half-life as does aspirin. That is, although aspirin has a “first” half-life as acetylsalicylic acid that is approximately 15 minutes followed by an active metabolite, salicylate, half-life of 3 to 5 hours, sodium salicylate has a single compartment active drug half-life of 3 to 5 hours, but can be prolonged up to 19 hours. The second major difference between aspirin and sodium salicylate is that aspirin acetylates and irreversibly blocks cyclooxgenase. Therefore, platelet aggregation is effectively inhibited for the life of the platelet with aspirin, whereas the antiplatelet adhesion effect is only temporary with the nonacetylated salicylates.
Sodium salicylate is considered somewhat less effective in reducing pain when compared with aspirin. However, some patients who are hypersensitive to aspirin may tolerate sodium salicylate.
- Related articles
- Related Qustion
- Anti-inflammatory Properties of Sodium Salicylate: Effects on Intracellular Signaling Pathways and Other Non-Cyclooxygenase Effects Jan 11, 2024
Sodium salicylate inhibits kinases and transcription factors, including NF-nB, while stimulating adenosine release, contributing to its anti-inflammatory effects.
- Sodium salicylate:Activity, Application and Chemical Studies Feb 15, 2023
Sodium Salicylate Sodium Salicylate is a NF-κB inhibitor that decreases inflammatory gene expression and improves repair in aged muscle.
Propionic acid (PA) is an important organic molecule of vast economic importance that includes food preservatives, flavoring agents, pharmaceutical formulations, textile and rubber auxiliaries, plasticizers, cosmetics, etc.....
Jan 20,2022Organic SolventsPyrrole is isoelectronic with a cyclopentadienyl anion but is electrically neutral because of the higher nuclear charge on nitrogen. The heteroatoms, N, O, and S, in the ring can be either neutral or carry a positive charge. In fact, hetero....
Jan 21,2022Organic ChemistrySodium salicylate
54-21-7You may like
Sodium salicylate manufacturers
- Sodium salicylate
-
- $0.00 / 1kg
- 2024-08-23
- CAS:54-21-7
- Min. Order: 1kg
- Purity: 99.0%
- Supply Ability: 1tons
- Sodium salicylate
-
- $0.00 / 25KG
- 2024-08-22
- CAS:54-21-7
- Min. Order: 25KG
- Purity: 98%min
- Supply Ability: 30tons/month
- Sodium Salicylate
-
- $8.70 / 1KG
- 2024-08-21
- CAS:54-21-7
- Min. Order: 10KG
- Purity: 99%
- Supply Ability: 10000kg