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LAPAQUISTAT

 структура
189060-13-7
CAS №
189060-13-7
английское имя:
LAPAQUISTAT
Синонимы:
TAK-475;CS-1400;LAPAQUISTAT;Lapaquistat Acetate;Lapaquistat Acetate (TAK-475);Lapaquistat and Lapaquistat Acetate;1-[[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid;2-[1-[2-[1-(3-Acetoxy-2,2-diMethylpropyl)-7-chloro-5(S)-(2,3-diMethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3(R)-yl]acetyl]piperidin-4-yl]acetic acid;4-Piperidineacetic acid, 1-[2-[(3R,5S)-1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-;2-(1-(2-((3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid
CBNumber:
CB01509119
Формула:
C33H41ClN2O9
молекулярный вес:
645.14
MOL File:
189060-13-7.mol

LAPAQUISTAT атрибут

Температура плавления: 194-196℃
Температура кипения: 826.4±65.0 °C(Predicted)
плотность: 1.246±0.06 g/cm3(Predicted)
температура хранения: Store at -20°C
растворимость: Хлороформ (Мало растворим), ДМСО (Мало растворим), метанол (Мало растворим)
пка: 4.66±0.10(Predicted)
форма: Твердый
цвет: белый
FDA UNII: IUH3AY74O3

Заявления о рисках и безопасности

LAPAQUISTAT химические свойства, назначение, производство

Использование

A novel squalene synthase inhibitor. Lapaquistat acetate decreased plasma cholesterol and triglyceride levels, by lowering lipoproteins containing apoB100. Treatment with Lapaquistat acetate increased collagen concentration and transformed coronary plaques into fibromuscular plaques. Lapaquistat acetate also suppressed the expression of matrix metalloproteinase-1 and plasminogen activator inhibitor-1 in the plaque and increased peripheral coenzyme Q10 levels.Antiarteriosclerotics.

LAPAQUISTAT препаратная продукция и сырье

сырьё

препарат


LAPAQUISTAT поставщик

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