N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt
N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt атрибут
| Температура плавления: |
104-108 °C(Solv: water (7732-18-5)) |
| температура хранения: |
Desiccate at RT |
| растворимость: |
ДМСО (Мало растворим), метанол (Мало растворим) |
| форма: |
Твердый |
| цвет: |
От белого до не совсем белого |
| FDA UNII: |
0CLL4232KD |
Заявления о рисках и безопасности
N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt химические свойства, назначение, производство
Использование
Treatment of acute lung injury; acute respiratory distress syndrome (elastase inhibitor).
Биологическая активность
Selective leukocyte elastase inhibitor (IC 50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF- κ B activation and LTB 4 -induced neutrophil transmigration in vitro . Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo .
N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt препаратная продукция и сырье
сырьё
препарат
N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt поставщик
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