Ангиотензин II (человека)
Ангиотензин II (человека) атрибут
| Температура кипения: |
809.08°C (rough estimate) |
| плотность: |
1.1257 (rough estimate) |
| показатель преломления: |
1.6700 (estimate) |
| RTECS: |
BW2165000 |
| температура хранения: |
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| растворимость: |
нерастворим в ДМСО; нерастворим в EtOH; ≥100,2 мг/мл в H2O |
| форма: |
пудра |
| пка: |
pK1: 10.37 (25°C) |
| цвет: |
оранжевый |
| Растворимость в воде: |
Растворим в воде (25 мг/мл) и 5% уксусной кислоте (1 мг/мл). |
| Последовательность: |
H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH |
| Стабильность:: |
Hygroscopic |
| ИнЧИКей: |
CZGUSIXMZVURDU-JZXHSEFVSA-N |
| Рейтинг продуктов питания EWG: |
1 |
| FDA UNII: |
M089EFU921 |
| Код УВД: |
C01CX09 |
Заявления о рисках и безопасности
Ангиотензин II (человека) химические свойства, назначение, производство
Описание
It is known that tumor tissues including metastatic lymph nodes are composed of
newly growing vessels which lack blood flow autoregulation and are influenced only
secondarily by the responding somatic vessels. Human angiotensin II (AT II). a
vasopressor, was introduced in Japan to improve the efficacy of systemic
chemotherapy. In patients with various advanced cancers, i.v. infusion of AT II to
achieve a mean blood pressure of 1.5 times of baseline (but not over 150 mm Hg)
followed by a bolus injection of conventional cytotoxic agents increases blood flow
5-7 fold in tumor tissues and therefore, increases drug delivery to the target tissue
resulting in enhanced chemotherapeutic effects. This induced-hypertension
chemotherapy regimen can be performed safely with minimal side effects.
Использование
Cardiopulmonary resuscitation - not yet an approved application
Общее описание
Functions in blood pressure maintenance. Stimulates the release of aldosterone from the adrenal gland. Has strong vasoconstrictive effects. Increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Activates JAK2 in smooth muscle cells. Activates p125FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates pp60c-src in vascular smooth muscle cells. Inhibits adenylate cyclase activity in spontaneously hypertensive rats.
Ангиотензин II (человека) препаратная продукция и сырье
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Ангиотензин II (человека) поставщик
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