Гепарин натрия
Гепарин натрия атрибут
| Температура плавления: |
>181°C (dec.) |
| альфа: |
D25 +47° (c = 1.5 in water) |
| температура хранения: |
2-8°C |
| растворимость: |
H2O: 50 мг/мл, прозрачный, бледно-желтый |
| форма: |
кристаллический (тонкий) |
| цвет: |
белый |
| РН: |
pH (10g/l, 25℃) : 6.0～8.0 |
| Биологические источники: |
Porcine intestinal mucosa |
| Растворимость в воде: |
Растворим в воде, диметилсульфоксиде и этаноле. |
| Мерк: |
14,4653 |
| Конкретная деятельность: |
≥180USP units/mg |
| Стабильность:: |
Стабильный. Несовместим с сильными окислителями, сильными основаниями. |
| Справочник по базе данных CAS: |
9041-08-1 |
| Рейтинг продуктов питания EWG: |
1 |
| Словарь онкологических терминов NCI: |
dalteparin sodium; Fragmin; Innohep |
| FDA UNII: |
ZZ45AB24CA |
| Словарь наркотиков NCI: |
dalteparin sodium |
| Система регистрации веществ EPA: |
Heparin, sodium salt (9041-08-1) |
| UNSPSC Code: |
41116107 |
| NACRES: |
NA.79 |
Гепарин натрия химические свойства, назначение, производство
Описание
Reviparin sodium, a second-generation low molecular weight heparin produced from
porcine mucosal heparin, has been introduced for the prevention of deep vein thrombosis and
pulmonary embolism following surgery. It has sustained activity and increased bioavailability
over unfractioned heparin. More noticeably, reviparin shows a pronounced inhibitory effect,
both in vitro and in vivo , on smooth muscle cell proliferation which plays a predominant role in
restenosis following angioplasty. Indeed, a lower incidence of restenosis without major
bleeding complications has been reported for reviparin treated patients who successfully
underwent percutaneous transluminal coronary angioplasty.
Химические свойства
off-white powder
Использование
Heparin sodium salt is used as a blood anti-coagulant. It is also used as an effective inhibitor of mesenchymal cell proliferation. Further, it binds to antithrombin III, which inhibits coagulation proteases. It is used as a major component of serum free media for preventing cell aggregation. It is also used as an anti-cancer agent in in vitro cancer research.
Общее описание
Heparin is mainly responsible for the delay in the coagulation of blood. It enhances the antithrombin-mediated inactivation of proteases in the coagulation pathway.
Методы очистки
Dissolve the salt in 0.1M NaCl (1g/100mL) and precipitate it by additing EtOH (150mL). [Wolfrom et al. J Org Chem 29 540 1946, Huggard Adv Carbohydr Chem 10 336-368 1955.]
Гепарин натрия препаратная продукция и сырье
сырьё
препарат
Гепарин натрия поставщик
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