RAC ALBUTEROL-D9

Salbutamol-d₉ is intended for use as an internal standard for the quantification of salbutamol (Item Nos. 21003 | 23991) by GC- or LC-MS. Salbutamol is an agonist of the β₂-adrenergic receptor (β₂-AR; K_d = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor). It is selective for β₂-ARs over β₁- and β₃-ARs (K_ds = 46.8 and 21.9 μM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs. It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 μg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC₅₀ = 39.7 μg). Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).

Off-White to Pale Yellow Solid

RAC ALBUTEROL-D9 is a labelled β2-adrenoceptor agonist,it is intended for use as an internal standard for the quantification of Albuterol by GC- or LC-mass spectrometry.