Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate
138923-03-2
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- CAS №
- 138923-03-2
- английское имя:
- Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate
- Синонимы:
- (1S,4R)-Methyl 4-aMinocyclopent-2-enecarboxylate;methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate;Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate;(1S,4R)-2-CYCLOPENTENE-1-CARBOXYLIC ACID, 4-AMINOMETHYL ESTER;(1S,4R)-Methyl 4-aMinocyclopent-2-enecarboxylate L-tartrate salt;Cis-(1S,4R)-4-aMino-2-Cyclopentene-1-carboxylic acid Methyl ester;2-Cyclopentene-1-carboxylic acid, 4-amino-, methyl ester, (1S,4R)-;2-Cyclopentene-1-carboxylicacid,4-amino-,methylester,(1S,4R)-(9CI)
- CBNumber:
- CB11286228
- Формула:
- C7H11NO2
- молекулярный вес:
- 141.17
- MOL File:
- 138923-03-2.mol
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Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate атрибут
Температура кипения: |
191.9±40.0 °C(Predicted) |
плотность: |
1.109±0.06 g/cm3(Predicted) |
температура хранения: |
2-8°C |
пка: |
9.66±0.40(Predicted) |
Заявления о рисках и безопасности
Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate химические свойства, назначение, производство
Использование
Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Синтез
Weigh 50g of the by-product (+)1-amino-4-carboxy-2-cyclopentene extracted by γ-lactam enzymatic resolution and put it in a flask, add 200g of water, and slowly add dropwise at 25~30℃ Sulfuric acid, adjust the pH value of the solution to 1~2, after the dripping is completed, add 0.1g of the racemic catalyst o-phthalaldehyde, then heat to reflux, and react for 10~15h. Concentrate under reduced pressure to no fraction, add 200ml of methanol, 20g of tartaric acid, cool to 10-20°C, filter and wash with methanol. Then add 20g of thionyl chloride and 100ml of methanol to the filter cake, react at 65°C for 8h and concentrate under reduced pressure until there is no fraction. Add 100ml of dichloromethane, stir to dissolve and wash the dichloromethane layer twice with drinking water to obtain (- ) Methyl 1-amino-4-carboxylate-2-cyclopentene in dichloromethane solution, yield 42%.
Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate препаратная продукция и сырье
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Methyl (1S,4R)-4-Amino-2-Cyclopentene-1-Carboxylate поставщик
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