Sulfизоксазол химические свойства, назначение, производство
Химические свойства
white to cream powder
Использование
Sulfisoxazole is a sulfonamide based antibacterial that exhibits activity against wide spectrum of gram-negative and gram-positive bacterium.
Определение
ChEBI: A sulfonamide antibacterial with an oxazole substituent. It has antibiotic activity against a wide range of gram-negative and gram-positive organisms.
Антимикробная активность
Like all examined sulfanilamides, this drug is effective in treating infections caused by
streptococci, gonococci, pneumococci, staphylococci, and also colon bacillus. However,
about 90% of it binds with proteins in the plasma after oral administration, and it diffuses mostly to tissues and tissue fluids, which makes it the drug of choice for many systemic infections. Synonyms of this drug are gantrisin, fultrxin, sulfazin, sulfolar, and
others.
Общее описание
Sulfisoxazole’s plasmahalf-life is 6 hours. This compound is a white, odorless,slightly bitter, crystalline powder. Its pKa is 5.0. At pH 6,this sulfonamide has a water solubility of 350 mg in100 mL, and its acetyl derivative has a solubility of 110 mgin 100 mL of water.Sulfisoxazole possesses the action and the uses of othersulfonamides and is used for infections involving sulfonamide-sensitive bacteria. It is claimed to be effective in thetreatment of Gram-negative urinary infections.
Реакции воздуха и воды
May be sensitive to prolonged exposure to air and light. Sensitive to heat. Slightly soluble in water.
Пожароопасность
Flash point data for Sulfisoxazole are not available; however, Sulfisoxazole is probably combustible.
Фармацевтические приложения
3,4-Dimethyl-5-sulfanilamidoisoxazole. It is highly soluble,
even in acid urine. The spectrum and potency are typical of
the group. It is well absorbed, achieving a concentration of
around 20 mg/L 3–4 h after a 2 g oral dose.
Side effects are those common to other sulfonamides. It
is less prone than some other members of the group to cause
renal problems. Its principal use is in urinary tract infection,
and is present in some ophthalmic preparations.
Биологическая активность
A selective ET A endothelin receptor antagonist (IC 50 values are 600 and 2200 nM for ET A and ET B receptors respectively).
Профиль безопасности
Mildly toxic by ingestion. An experimental teratogen. Questionable carcinogen. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.
Sulfизоксазол препаратная продукция и сырье
сырьё
препарат