D(+)-раффиноза пентагидра химические свойства, назначение, производство
Описание
D-(+)-Raffinose is a trisaccharide composed of galactose, glucose, and fructose that occurs naturally in a variety of vegetables and grains. It is hydrolyzed to galactose and sucrose by α-galactosidase.
Методы производства
Raffinose occurs naturally in Australian manna, cottonseed meal,
and seeds of various food legumes. It can be isolated from beet sugar
molasses through sucrose separation, seed-crystallization, and
filtration.
Фармацевтические приложения
Raffinose is a trisaccharide carbohydrate that is used as a bulking
agent, blood substitute, stabilizing agent, and water scavenger in
freeze-drying where it acts as a stabilizer for freeze-dried formulations. It is also used as a crystallization inhibitor in sucrose
solutions.
Безопасность
Raffinose is a naturally occurring trisaccharide investigated for use
in freeze-dried pharmaceutical formulations. It occurs in a number
of plants that are consumed widely.
хранилище
Raffinose is stable under ordinary conditions of use and storage.
Excessive heat should be avoided to prevent degradation. Thermal decomposition products are carbon monoxide and carbon dioxide.
Методы очистки
fructo-furanose [17629-30-0 (5H2O), 512-69-6 (anhydrous)] M 594.5, m 8 0o, 80 -82o, +124o (c 10, H2O), [ ] D +105o (c 1 for pentahydrate, H2O), pK 1 12.40, pK 2 13.44, pK 3 13.52. D(+)-Raffinose crystallises from H2O, 90% aqueous EtOH or MeOH as the pentahydrate. The anhydrous sugar has m 132-135o. It has RF 0.8 on TLC (Silica Gel, and 1:3:3 CHCl3/butanone:/MeOH). The undecaacetate has been purified through an alumina column by elution with CHCl3, and recrystallised from EtOH/MeOH/H2O (3:2:5), with m 99-100o, [] D +92.8o (c 5.14, EtOH). [pK : Coccioli & Vicedomini Ann Chim (Rome) 66 269, 275 1976, 1H NMR: Suami et al. Carbohydr Research 26 234 1973, Beilstein 17 III/IV 3801, 17/8 V 403.]
Несовместимости
Raffinose is incompatible with strong oxidizers.
Регуляторный статус
Raffinose is a naturally occurring trisaccharide and is consumed as
part of a normal diet.
D(+)-раффиноза пентагидра препаратная продукция и сырье
сырьё
препарат