Орлистат
Орлистат атрибут
Температура плавления: |
<50 °C |
Температура кипения: |
615.9±30.0 °C(Predicted) |
альфа: |
D20 -32.0° (c = 1 in chloroform) |
плотность: |
0.976±0.06 g/cm3(Predicted) |
температура хранения: |
2-8°C |
растворимость: |
ДМСО: 19 мг/мл |
форма: |
Твердый |
пка: |
14.59±0.23(Predicted) |
цвет: |
белый |
Мерк: |
14,6869 |
Стабильность:: |
Растворы в ДМСО или этаноле можно хранить при -20° до 1 недели. |
ИнЧИКей: |
AHLBNYSZXLDEJQ-FWEHEUNISA-N |
SMILES: |
C(O[C@H](C[C@H]1[C@H](CCCCCC)C(=O)O1)CCCCCCCCCCC)(=O)[C@H](CC(C)C)NC=O |
Справочник по базе данных CAS: |
96829-58-2(CAS DataBase Reference) |
FDA UNII: |
95M8R751W8 |
Код УВД: |
A08AB01 |
безопасность
- Заявления о рисках и безопасности
- код информации об опасности(GHS)
символ(GHS) |
|
сигнальное слово |
Warning |
Заявление об опасности |
пароль |
Заявление об опасности |
Класс опасности |
категория |
сигнальное слово |
пиктограмма |
предупреждение |
H302 |
Вредно при проглатывании. |
Острая токсичность, пероральная |
Категория 4 |
Предупреждение |
![](/GHS07.jpg) |
P264, P270, P301+P312, P330, P501 |
H412 |
Вредно для водных организмов с долгосрочными
последствиями. |
Опасность для водной среды, долгосрочная опасность |
Категория 3 |
|
|
P273, P501 |
|
Внимание |
P273 |
Избегать попадания в окружающую среду. |
|
Орлистат химические свойства, назначение, производство
Описание
Orlistat was launched in the UK as Xenical for the long-term treatment
of obesity, preferably in conjunction with a moderately reduced calorie diet.
Orlistat is a tetrahydro-derivative of the natural hypolipaemic lipstatin (from
Streptomyces toxyfncini) and can be obtained either by hydrogenation of
lipstatine or by several different synthetic ways involving many steps from ( S ) -
rnalic acid. Orlistat is a potent inhibitor of gastrointestinal lipases required for the
lipolysis and digestion of dietary fat, in particular of pancreatic lipase ; as a
result, it prevents the absorption of about one third of the fat contained in food
and acts as an effective weight-reducing therapy. The outcomes of several
clinical trials involving thousands of obese patients showed that Orlistat
promotes a significant weight loss (often between 5 and 10% after one year) and
improves cardiovascular risk factors such as total cholesterol, LDL/HDL ratio,
blood glucose levels, insulin, blood pressure. Orlistat has minimal systemic
absorption, the majority of the compound itself being recovered in the feces ; it
does not affect other gastrointestinal processes, or the absorption of other
rnacronutrients such as carbohydrates and proteins.
Химические свойства
Off-White Solid
Использование
Orlistat is an antiobesity agent. Orlistat is an pancreatic lipase inhibitor.
Общее описание
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Orlistat is a specific lipase inhibitor derived from lipostatin, which is naturally produced by Streptomyces toxytricini. Lipase inhibition induced by orlistat reduces the absorption of dietary fat, thereby contributing to caloric deficit.
Биологическая активность
Hypolipemic pancreatic, gastric and carboxylester lipase inhibitor. Exhibits no activity at phospholipase A 2 , liver esterase, trypsin and chymotrypsin. Inhibits the thioesterase domain of fatty acid synthase, leading to cell cycle arrest at the G 1 /S boundary in vitro . Prevents the absorption of approximately one third of fat from food and exhibits progastrokinetic, antiobesity and antihypercholesterolemic activity in vivo .
Орлистат препаратная продукция и сырье
сырьё
препарат
Орлистат поставщик
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96829-58-2(Орлистат)подобный поиск: