D-глюкозы моногидрата химические свойства, назначение, производство
Описание
D-(+)-Glucose monohydrate, commonly known as glucose or dextrose, has several microbiological applications. It is used as a carbon source in microbial culture media to promote the growth and propagation of various microorganisms. Glucose is a simple sugar and a primary energy source for bacterial cell metabolism. It is a common natural sugar involved in processes such as energy production, glycosylation, and formation of glycans that provide structure to cells. It is involved in a detrimental process in cells called glycation.
Химические свойства
D-Glucose monohydrate is white or almost white, crystalline powder.
Использование
Replenisher (fluid and nutrient).
Методы производства
Dextrose, a monosaccharide sugar, occurs widely in plants and is manufactured on a large scale by the acid or enzymatic hydrolysis of starch, usually maize (corn) starch. Below 50°C a-D-dextrose monohydrate is the stable crystalline form produced; above 50°C the anhydrous form is obtained; and at still higher temperatures b-D-dextrose is formed, which has a melting point of 148–155°C.
Определение
A monosaccharide occurring
widely in nature as D-glucose. It occurs
as glucose units in sucrose, starch, and
cellulose. It is important to metabolism because
it participates in energy-storage and
energy-release systems.
Фармацевтические приложения
Dextrose is widely used in solutions to adjust tonicity and as a sweetening agent.Dextrose is also used as a wet granulation diluent and binder, primarily in chewable tablets.Although dextrose is comparable as a tablet diluent to lactose, tablets produced with dextrose monohydrate require more lubrication, are less friable, and have a tendency to harden. The mildly reducing properties of dextrose may be used when tableting to improve the stability of active materials that are sensitive to oxidation.
Dextrose is also used therapeutically and is the preferred source of carbohydrate in parenteral nutrition regimens.
Сельскохозяйственное использование
Glucose is a monosaccharide sugar found in honey and fruits. It is the primary product of plant photosynthesis, which is optically active and dextrorotatory.
Glucose and its derivatives are critically important in the energy metabolism of living organisms. It is transported around the animal body through blood, and by lymph and cerebrospinal fluid, to cells where the energy is released during glycolysis.
Fructose, the stereoisomer of glucose, occurs in green plants, fruits and honey. It is sweeter than sucrose.
Yeasts readily ferment glucose to produce ethyl alcohol and carbon dioxide. It is also metabolized by bacteria into acetic and butyric acids, lactic acid, butyl alcohol, acetone, hydrogen, carbon dioxide and many other compounds.
Plants and animals convert complex carbohydrates (like starch and glycogen) into glucose to meet their energy needs. Glucose is produced commercially by hydrolysing corn starch with dilute mineral acid. Commercial glucose is mostly used in the manufacture of confections and in the canning industry.
Безопасность
D-Glucose monohydrate is rapidly absorbed from the gastrointestinal tract. It is metabolized to carbondioxide and water with therelease ofenergy.
Concentrated D-Glucose monohydrate solutions given by mouth may cause nausea and vomiting. D-Glucose monohydrate solutions of concentration greater than 5% w/v are hyperosmotic and are liable to cause local vein irritation following intravenous administration. Thrombophlebitis has been observed following the intravenous infusion of isoosmotic D-Glucose monohydrate solution with low pH, probably owing to the presence of degradation products formed by overheating during sterilization. The incidence of phlebitis may be reduced by adding sufficient sodium bicarbonate to raise the pH of the infusion above pH 7.
LD50 (mouse, IV): 9g/kg
LD50 (rat, oral): 25.8g/kg
Физиологические эффекты
Dextrose Monohydrate is the monohydrate form of D-glucose, it restore blood glucose levels, provide calories, may aid in minimizing liver glycogen depletion and exerts a protein-sparing action.Dextrose Monohydratealso plays a role in the production of proteins and in lipid metabolism.
Химические свойства
Белое кристаллическое вещество сладкого вкуса, растворимое в воде и органических растворителях.
Применение
пищевой промышленности, как заменитель сахарозы, кондитерской промышленности при изготовлении мягких конфет, десертных сортов шоколада, тортов и различных диетических изделий, хлебопечении глюкоза улучшает условия брожения, придает пористость и хороший вкус изделиям, замедляет очерствение, производстве мороженого она занижает точку замерзания, увеличивает его твердость, производстве фруктовых консервов, соков, ликеров, вин, безалкогольных напитков, так как глюкоза не маскирует аромата и вкуса, молочной промышленности при изготовлении молочных продуктов и продуктов детского питания,рекомендуется использовать глюкозу в определенной пропорции с сахарозой для придания этим продуктам более высокой питательной ценности, ветеринарии, птицеводстве, фармацевтической промышленности.
Производство
Декстроза, моносахаридный сахар, широко встречается в растениях и производится в большом масштабе путем кислотной или ферментативной гидролиза крахмала, обычно кукурузного. При температурах ниже 50°C образуется устойчивая кристаллическая форма a-D-декстрозы моногидрата; при температурах выше 50°C получается бесводная форма; и при еще более высоких температурах образуется b-D-декстроза, которая имеет температуру плавления 148-155°C.
хранилище
D-Glucose monohydrate has good stability under dry storage conditions. Aqueous solutions may be sterilized by autoclaving. However, excessive heating can cause a reduction in pH and caramelization of solutions.
Thebulkmaterialshouldbestoredinawell-closedcontainerina cool, dry place.
Несовместимости
Dextrose solutions are incompatible with a number of drugs such as cyanocobalamin, kanamycin sulfate, novobiocin sodium, and warfarin sodium. Erythromycin gluceptate isunstable indextrose solutions at a pH less than 5.05. Decomposition of B-complex vitamins may occur if they are warmed with dextrose.
In the aldehyde form, dextrose can react with amines, amides, amino acids, peptides, and proteins. Brown coloration and decomposition occur with strong alkalis.
Dextrose may cause browning of tablets containing amines (Maillard reaction).
Регуляторный статус
Included in the FDA Inactive Ingredients Database (capsules; inhalations; IM, IV, and SC injections; tablets, oral solutions, and syrups). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
D-глюкозы моногидрата препаратная продукция и сырье
сырьё
препарат