AMG 925 химические свойства, назначение, производство
Описание
AMG 925 is a dual inhibitor of FMS-related tyrosine kinase 3 (FLT3) and cyclin-dependent kinase 4 (Cdk4; IC50s = 1 and 3 nM, respectively). It is selective for FLT3 and Cdk4 over Cdk1 (IC50 = 2.22 μM). AMG 925 also binds to FLT3ITD, FLT3D835Y, FLT3D835H, FLT3K663Q, and FLT3N841I (Kds = 1-4 nM). It inhibits proliferation of MOLM-13, COLO 205, and U937 cancer cells (IC50s = 19, 55, and 52 nM, respectively). AMG 925 (50, 75, and 150 mg/kg) reduces intratumor levels of pSTAT5 and pRb and inhibits tumor growth in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model.
AMG 925 препаратная продукция и сырье
сырьё
2,4-Pyrimidinediamine, N4-(trans-4-methylcyclohexyl)-
1401033-82-6
2,4-Pyrimidinediamine, 5-iodo-N4-(trans-4-methylcyclohexyl)-
9H-Pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine, 9-(trans-4-methylcyclohexyl)-
2-methylpropan-2-yl 2-({9-[(1r,4r)-4-methylcyclohexyl]pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-5,6,7,8-tetrahydropyrido[4,3-b]pyridine-6-carboxylate
Транс-4-метилциклогексиламин
tert-butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate
транс-4-метилциклогексиламин гидрохлорид
2-ХЛОРО-5,6,7,8-ТЕТРАГИДРО-1,6-НАФТИРИДИН ГИДРОХЛОРИД
Гликолевая кислота
3-фторпиридин
препарат