ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate

307519-88-6

CAS №: 307519-88-6

английское имя:: ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate

Синонимы:: NMDI14;NMDI14 >=97% (HPLC);inhibit,Inhibitor,NMDI14,NMDI-14,NMDI 14;ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate;3-Thiophenecarboxylic acid, 4,5-dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-, ethyl ester

CBNumber:: CB33589260

Формула:: C21H25N3O4S

молекулярный вес:: 415.51

MOL File:: 307519-88-6.mol

атрибут

безопасность

использование

поставщик 24

продукт поиска:

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate атрибут

Температура кипения:	658.8±55.0 °C(Predicted)
плотность:	1.250±0.06 g/cm3(Predicted)
температура хранения:	2-8°C
растворимость:	DMSO : ≥ 25 mg/mL (60.17 mM)
пка:	13.42±0.40(Predicted)
форма:	пудра
цвет:	От белого до бежевого

Заявления о рисках и безопасности

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate химические свойства, назначение, производство

Использование

NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:

to study its effects on differentiating cardiomyocytes
to study its effects on zebrafish pdzk1 gene-knockout embryos
to analyze its effects on the apoptosis of colorectal cancer cells

Биохимия/физиол Действия

NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate препаратная продукция и сырье

сырьё

препарат

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate поставщик

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