Модафинил
Модафинил атрибут
Температура плавления: |
164-166°C |
Температура кипения: |
559.1±50.0 °C(Predicted) |
плотность: |
1.283±0.06 g/cm3(Predicted) |
Fp: |
2℃ |
температура хранения: |
Store at +4°C |
растворимость: |
ДМСО: 18 мг/мл, растворимый |
форма: |
Белое твердое вещество |
пка: |
14.88±0.40(Predicted) |
цвет: |
белый |
BCS Class: |
4 |
Справочник по базе данных CAS: |
68693-11-8(CAS DataBase Reference) |
Словарь онкологических терминов NCI: |
modafinil |
FDA UNII: |
R3UK8X3U3D |
Словарь наркотиков NCI: |
modafinil |
Код УВД: |
N06BA07 |
Модафинил химические свойства, назначение, производство
Описание
Modafinil, a centrally active α1-adrenergic agonist, was marketed in France as a
psychostimulant for the treatment of narcolepsy and idiopathic hypersomnia
including Gelineau's syndrome. In monkeys, modafinil was found to induce potent
behavioral stimulation and awakening without stereotyped behavior. In narcoleptic
patients, modafinil reduces the daily number of sleep attacks significantly and
markedly improves performance. The mechanism of action for its locomotor effects
was reported to be due to the stimulation of the central α1-adrenergic system,
opposite to amphetamine and methylphenidate, which act mainly by dopaminergic
mechanisms. Modafinil has been reported to exhibit minimal peripheral side effects
at therapeutic doses and appears to have low abuse potential. The use of modafinil
in the treatment of cerebral infarction and ischemia has been claimed.
Химические свойства
Crystalline Solid
Использование
Modafinil is an α-1-adrenergic agonist. Modafinil is a CNS stimulant; psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease.
Общее описание
Modafinil (Provigil) has overall wakefulness-promotingproperties similar to those of central sympathomimetics. It isconsidered an atypical α1-norepinephrine (NE) receptorstimulant and is used to treat daytime sleepiness in narcolepsypatients. Adverse reactions at therapeutic doses arereportedly not severe and may include nervousness, anxiety,and insomnia. Modafinil is used by oral administration.
Биологическая активность
Psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease. Promotes vigilence and wakefulness without the central and peripheral side effects associated with conventional dopaminergic psychostimulants. Mechanism of action is not fully understood, possibly via modulation of catecholamine/GABAergic neurotransmission.
Модафинил препаратная продукция и сырье
сырьё
препарат
68693-11-8(Модафинил)подобный поиск: