7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2)

1216720-69-2

CAS №: 1216720-69-2

английское имя:: 7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2)

Синонимы:: SCH 79797 (hydrochloride);N3-Cyclopropyl-7-(4-isopropylbenzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride;7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2);infarct,SCH79797 dihydrochloride,SCH-79797 dihydrochloride,SCH-79797,SCH79797,Inhibitor,inhibit,Nonpeptide,thrombin,wortmannin,SCH 79797,antiproliferative,platelets,Protease Activated Receptor (PAR),pro-apoptotic,thrombosis,Thrombin receptors,PAR1,cardioprotection,Apoptosis

CBNumber:: CB52627190

Формула:: C23H26ClN5

молекулярный вес:: 407.95

MOL File:: 1216720-69-2.mol

атрибут

безопасность

использование

поставщик 27

продукт поиска:

7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2) атрибут

температура хранения:	Store at 2-8°C, protect from light
растворимость:	Растворим до 25 мМ в этаноле и до 50 мМ в ДМСО.
форма:	пудра
цвет:	White to yellow

Заявления о рисках и безопасности

7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2) химические свойства, назначение, производство

Описание

SCH 79797 is a non-peptide antagonist of proteinase-activated receptor 1 (PAR1). It blocks binding of the high affinity thrombin receptor-activating peptide (haTRAP) (IC₅₀ = 70 nM) as well as platelet aggregation induced by either haTRAP or α-thrombin (IC₅₀ = 0.3 and 3 μM, respectively). SCH 79797 has no activity against PAR2, PAR4, or other receptors involved in platelet activation. It also blocks PAR1 activation on vascular smooth muscle cells and endothelial cells.

Использование

N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine Dihydrochloride is a selective PAR1 antagonist which was shown to limit myocardial ischemia/reperfusion injury in rat hearts.

7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2) препаратная продукция и сырье

сырьё

препарат

7H-Pyrrolo[3,2-f]quinazoline-1,3-diaMine, N3-cyclopropyl-7-[[4-(1-Methylethyl)phenyl]Methyl]-, (Hydrochloride) (1:2) поставщик

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