Procaine penicilline G hydrate

White Solid

Procaine penicilline G hydrate is a composed of the β-lactam antibiotic of Penicillin G and the sodium channel blocker Procaine. As an antibiotic, Penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Procaine Penicillin G is used a growth stimulant for poultry.

The procaine salt of benzylpenicillin. Poorly soluble (1:200 in water). Administered intramuscularly as a suspension of crystals which slowly dissolve at the site of the injection.
It must not be given intravenously. Intramuscular administration produces a flat sustained plasma concentration of penicillin, which is much lower than that achieved by an equivalent dose of benzylpenicillin, with plasma levels still detectable 24 h later. An injection of 0.6 g yields a peak plasma concentration of 1–2 mg benzylpenicillin/L after 2–4 h. Free procaine is detectable in the plasma within 30 min.
Very severe and potentially fatal reactions resembling those of anaphylactic shock, but non-allergic in character, may occur, probably due to accidental entry into the vascular system at the site of injection and blockage of pulmonary and cerebral capillaries by crystals of the suspension. Reactions due to liberated procaine may include acute anxiety, hypertension, tachycardia, vomiting, audiovisual hallucinations and acute psychotic disturbance. The most severe reactions lead to convulsions and cardiac arrest. Other reactions are those to liberated benzylpenicillin.