Пирогаллол химические свойства, назначение, производство
Химические свойства
White or nearly white needle- or
leaf-shaped crystals or crystalline powder.Pyrogallol is practically odorless.
Использование
Pyrogallol possesses importance as a spectrophotometric reagent in the determination of niobium and tantalum. The absorptions of niobium and tantalum complexes are usually measured at 340 and 335 nm, respectively. The niobium complex is formed in slightly acidic medium, and the tantalum complex in strongly acidic medium (4 N HC1). The absorption spectra are pH-dependen.
Методы производства
Pyrogallol is prepared by heating dried gallic acid at about
200°C with the loss of carbon dioxide or by the
chlorination of cyclohexanol to tetrachlorocyclohexanone,
followed by hydrolysis.
Определение
ChEBI: A benzenetriol carrying hydroxy groups at positions 1, 2 and 3.
Общее описание
Odorless white to gray solid. Sinks and mixes with water.
Реакции воздуха и воды
Turns gray on exposure to light or air. Water soluble.
Профиль реактивности
Pyrogallol is a strong reducing agent. Reacts with alkalis, NH3, antipyrine, camphor, phenol, iron and lead salts, iodine, lime water, menthol and KMnO4.
Опасность
Toxic by ingestion and skin absorption.
Угроза здоровью
Inhalation of dust causes irritation of nose and throat. Ingestion may cause severe gastrointestinal irritation, convulsions, circulatory collapse, and death. Contact with eyes causes irritation. Skin contact can cause local discoloration, irritation, eczema, and death; repeated contact can cause sensitization.
Пожароопасность
Pyrogallol is probably combustible.
Контактные аллергены
Pyrogallol belongs to the phenols group. It is an old
photograph developer and a low sensitizer in hair dyes.
Профиль безопасности
Human poison by ingestion and subcutaneous routes. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported.
1 198 PPRSOO PYROSULFURYL CHLORIDE
Readdy absorbed through the skin. Human systemic effects by ingestion: convulsions, dyspnea, gastrointestinal effects. A severe skin and eye irritant. Incompatible with alkalies, NH3, antipyrine, phenol, iron and lead salts, iodine, KMn04. When heated to decomposition it emits acrid smoke and irritating fumes. Used as a topical antibacterial agent, as an intermediate, hair dye component, and analytical reagent.
Канцерогенность
Pyrogallol was not carcinogenic
in mouse and rabbit chronic dermal studies. Mice were
treated twice weekly with pyrogallol in acetone (50%) on
the shaved flank for life. There was no increase in dermal or
systemic tumors. A similar study in rabbits also
revealed no skin tumors, although positive controls showed
an increase in tumors in both mice and rabbits.
Pyrogallol was considered to be cocarcinogenic when
administered dermally three times a week together with
the skin carcinogen benzo[a]pyrene for 440 days;
pyrogallol administered alone caused no increase in skin
tumors.
Пирогаллол препаратная продукция и сырье
сырьё
препарат
Убидекаренон
BENDIOCARB
Exifone
GALLEIN
4-гидроксибутилакрила
1,2,3-Триметоксибензол
1-ХЛОРМЕТИЛ-2,3,4-ТРИМЕТОКСИБЕНЗОЛ
7,8-дигидрокси-4-метилкумарин
1,4-Бутандиол диакрила
Галламина триэтйодид
Атракурия безилат
1,3-Benzenediol, 2,5-dimethoxy-
7,8-гидрат Dihydroxyflavone
7,8-Dihydroxycoumarin
2'-ГИДРОКСИ-3 ', 4'-ДИМЕТОКСИАЦЕТОФЕНОН
5-ТЕР-БУТИЛПИРОГАЛЛОЛ
C.I.Mordant Green 22
GALLEIN