OPC 21268
OPC 21268 атрибут
| Температура кипения: |
772.5±60.0 °C(Predicted) |
| плотность: |
1?+-.0.06 g/cm3(Predicted) |
| температура хранения: |
2-8°C |
| растворимость: |
ДМСО: ≥20 мг/мл |
| пка: |
16.17±0.46(Predicted) |
| форма: |
пудра |
| цвет: |
От белого до не совсем белого |
OPC 21268 химические свойства, назначение, производство
Описание
OPC 21268 is a nonpeptide antagonist of vasopressin V1 receptors (IC50 = 0.4 μM in rat liver membranes). It is selective for V1 over V2 receptors (IC50 = >100 μM in kidney membranes). It is also selective for rat over human V1 receptors (Kis = 25 and 8,800 nM, respectively), which can be partially attributed to the alanine residue at position 337 of the rat sequence, instead of a glycine residue in the human sequence, with differences at positions 224, 310, and 324 also contributing. OPC 21268 (0.03-1 mg/kg, i.v.) inhibits pressor responses induced by arginine vasopressin (argipressin; ) in pithed rats and arginine vasopressin-induced vasoconstriction in conscious rats (ID50 = 2 mg/kg). It induces hypotension in aged spontaneously hypertensive rats (SHRs) and stroke-prone SHRs when administered at a dose of 3 mg/kg.
Использование
OPC 21268 is a nonpeptide AVP (Vasopressin) Receptor V antagonist.
OPC 21268 препаратная продукция и сырье
сырьё
препарат
OPC 21268 поставщик
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