TRIETHYLENEMELAMINE химические свойства, назначение, производство
Использование
Triethylenemelamine (TEM) is a potent mutagen. It has
little, if any, industrial application. TEM is mainly used in
medicine as an antineoplastic agent and as a “positive control”
in many in vitro and in vivo mutagenicity assays.
Общее описание
Odorless white crystalline powder. Melting point 160°C, then rapidly polymerizes to a white solid. Almost immediate degradation at pH 3.0; rapid degradation at pH 5.0; and very little degradation at pH 7.5.
Реакции воздуха и воды
Soluble in water [Hawley]. Polymerizes readily with heat or moisture.
Профиль реактивности
TRIETHYLENEMELAMINE polymerizes readily with heat or moisture. Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
Пожароопасность
Flash point data for TRIETHYLENEMELAMINE are not available; however, TRIETHYLENEMELAMINE is probably combustible.
Профиль безопасности
Poison by ingestion,
intraperitoneal, intramuscular, intravenous,
and subcutaneous routes. Experimental
teratogenic and reproductive effects.
Questionable carcinogen with experimental
neoplastigenic and tumorigenic data. Human
mutation data reported. Can cause
gastrointestinal tract disturbances and bone
marrow depression. When heated to
decomposition it emits highly toxic fumes of
NOx. Used as an antineoplastic agent and as
an insect sterilant.
Канцерогенность
In several older, limited studies,
triethylenemelamine reportedly produced tumors in mice by
the dermal and intraperitoneal routes and in rats by subcutaneous
and/or intramuscular administration. These data were
reviewed and evaluated by the IARC and judged as
“limited evidence of carcinogenicity in animals.” As a result
of this evaluation of the animal data and a lack of evidence of
carcinogenicity in humans, the IARC placed TEM in its
Group 3 category.
TRIETHYLENEMELAMINE препаратная продукция и сырье
сырьё
препарат