ISOCORYDINE HYDROCHLORIDE
ISOCORYDINE HYDROCHLORIDE атрибут
| Температура плавления: |
216-220 °C(lit.) |
| альфа: |
D20 +195° (chloroform) |
| Температура кипения: |
477.03°C (rough estimate) |
| плотность: |
1.2064 (rough estimate) |
| показатель преломления: |
1.5614 (estimate) |
| растворимость: |
Растворим в хлороформе, дихлорметане, этилацетате, ДМСО, ацетоне и т. д. |
| форма: |
Кристалл. |
| пка: |
9.41±0.20(Predicted) |
| FDA UNII: |
3B5E87JEOX |
Заявления о рисках и безопасности
| WGK Германия |
3 |
| RTECS |
CE1057950 |
| Токсичность |
LD50 intraperitoneal in mouse: 104mg/kg |
ISOCORYDINE HYDROCHLORIDE химические свойства, назначение, производство
Описание
Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities. It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 μM. Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC50 value of 12.6 μM. It is cytotoxic to A549 lung cancer cells (IC50 = 197.7 μM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC50s = 161.3, 148, 262.2, and 254.1 μg/ml, respectively). Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.
Использование
sedative, cholinergic
использованная литература
See Isocorydine
ISOCORYDINE HYDROCHLORIDE препаратная продукция и сырье
сырьё
препарат
ISOCORYDINE HYDROCHLORIDE поставщик
Global( 122)Suppliers
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