PF-04457845

1020315-31-4

CAS №: 1020315-31-4

английское имя:: PF-04457845

Синонимы:: CS-1549;PF-04457845;PF-04457845;PF04457845;PF-04457845 >=98% (HPLC);Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor;N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide;N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide;N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide;1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]-

CBNumber:: CB62522724

Формула:: C23H20F3N5O2

молекулярный вес:: 455.43

MOL File:: 1020315-31-4.mol

атрибут

безопасность

использование

поставщик 56

продукт поиска:

PF-04457845 атрибут

Температура кипения:	687.0±55.0 °C(Predicted)
плотность:	1.389±0.06 g/cm3(Predicted)
температура хранения:	room temp
растворимость:	DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
пка:	12.72±0.20(Predicted)
форма:	пудра
цвет:	От белого до бежевого
FDA UNII:	H4C81M8YYW

Заявления о рисках и безопасности

WGK Германия	3

PF-04457845 химические свойства, назначение, производство

Биохимия/физиол Действия

PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg.

PF-04457845 препаратная продукция и сырье

сырьё

Pyridine, 2-[3-(4-piperidinylidenemethyl)phenoxy]-5-(trifluoromethyl)-, hydrochloride (1:1) Phosphonic acid, P-[[3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]phenyl]Methyl]-, diethyl ester CarbaMic acid, N-3-pyridazinyl-, phenyl ester BenzeneMethanol, 3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]- Pyridine, 2-[3-(chloroMethyl)phenoxy]-5-(trifluoroMethyl)- 3-гидроксибензиловый спир 2-Хлор-5-(трифторметил) пиридина

препарат

PF-04457845 поставщик

Global( 56)Suppliers

поставщик	телефон	страна	номенклатура продукции	благоприятные условия
Amadis Chemical Company Limited	571-89925085	China	131957	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	China	40066	58
Aladdin Scientific	+1-+1(833)-552-7181	United States	57505	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	China	33338	58
LEAPCHEM CO., LTD.	+86-852-30606658	China	43340	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	China	10986	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8467	58
TargetMol Chemicals Inc.		United States	38466	58
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6391	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32072	58