Агар химические свойства, назначение, производство
Химические свойства
Agar occurs as transparent, odorless, tasteless strips or as a coarse
or fine powder. It may be weak yellowish-orange, yellowish-gray to
pale-yellow colored, or colorless. Agar is tough when damp, brittle
when dry.
Вхождение
Agar is found in several species of red marine algae in oceans around the world.
Использование
Agar is a gum obtained from red seaweeds of the genera gelidium,
gracilaria, and eucheuma, class rhodophyceae. it is a mixture of the
polysaccharides agarose and agaropectin. it is insoluble in cold
water, slowly soluble in hot water, and soluble in boiling water,
forming a gel upon cooling. the gels are characterized as being
tough and brittle, setting at 32–40°c, and melting at 95°c. a rigid,
tough gel can be formed at 0.5%. agar mainly functions in gel for-
mation because of its range between melting and setting tempera-
tures, being used in piping gels, glazes, icings, dental impression
material, and microbiological plating. typical use levels are
0.1–2.0%.
Определение
agar: An extract of certain species ofred seaweeds that is used as a gellingagent in microbiological culturemedia, foodstuffs, medicines, andcosmetic creams and jellies. Nutrientagar consists of a broth made frombeef extract or blood that is gelledwith agar and used for the cultivationof bacteria, fungi, and somealgae.
Методы производства
Agar is obtained by freeze-drying a mucilage derived from Gelidium
amansii Lamouroux, other species of the same family (Gelidiaceae),
or other red algae (Rhodophyta).
Общее описание
Tan powder.
Реакции воздуха и воды
Water insoluble.
Профиль реактивности
Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. They exhibit both weak acid and weak base behavior.
Пожароопасность
Flash point data for Agar are not available. Agar is probably combustible.
Фармацевтические приложения
Agar is widely used in food applications as a stabilizing agent. In
pharmaceutical applications, agar is used in a handful of oral tablet
and topical formulations. It has also been investigated in a number
of experimental pharmaceutical applications including as a
sustained-release agent in gels, beads, microspheres, and tablets.It has also been reported to work as a disintegrant in tablets.
Agar has been used in a floating controlled-release tablet; the
buoyancy in part being attributed to air entrapped in the agar gel
network.It can be used as a viscosity-increasing agent in aqueous
systems. Agar can also be used as a base for nonmelting, and
nondisintegrating suppositories.Agar has an application as a
suspending agent in pharmaceutical suspensions.
Профиль безопасности
Mildly toxic by ingestion. When heated to decomposition it emits acrid smoke and fumes.
Безопасность
Agar is widely used in food applications and has been used in oral
and topical pharmaceutical applications. It is generally regarded as
relatively nontoxic and nonirritant when used as an excipient.
LD50 (hamster, oral): 6.1 g/kg
LD50 (mouse, oral): 16.0 g/kg
LD50 (rabbit, oral): 5.8 g/kg
LD50 (rat, oral): 11.0 g/kg
хранилище
Agar solutions are most stable at pH 4–10.
Agar should be stored in a cool, dry, place. Containers of this
material may be hazardous when empty since they retain product
residues (dust, solids).
Несовместимости
Agar is incompatible with strong oxidizing agents. Agar is
dehydrated and precipitated from solution by ethanol (95%).
Tannic acid causes precipitation; electrolytes cause partial dehydration
and decrease in viscosity of sols.
Регуляторный статус
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (oral tablets).
Included in the Canadian List of Acceptable Non-medicinal
Ingredients. Included in nonparenteral medicines licensed in the UK.
Агар препаратная продукция и сырье
сырьё
препарат