L(-)-фенилэфрин гидрохлорид химические свойства, назначение, производство
Описание
R-(-)-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 μM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 μM, respectively). By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine . This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents.
Химические свойства
white to almost white crystalline powder
Использование
(R)-Phenylephrine Hydrochloride is an α-Adrenergic agonist. Mydriatic; decongestant.
Определение
ChEBI: A hydrochloride that is the monohydrochloride salt of phenylephrine.
Общее описание
Odorless white microcrystalline powder. Bitter taste. pH (1% aqueous solution) about 5.
Реакции воздуха и воды
May be sensitive to prolonged exposure to air and light. Water soluble.
Профиль реактивности
Phenylephrine hydrochloride is incompatible with acids, acid chlorides, acid anhydrides and oxidizing agents. Phenylephrine hydrochloride is also incompatible with butacaine, alkalis and ferric salts.
Пожароопасность
Flash point data for Phenylephrine hydrochloride are not available; however, Phenylephrine hydrochloride is probably combustible.
Биологическая активность
α 1 -adrenoceptor agonist; pK i values are 5.86, 4.87 and 4.70 for α 1D , α 1B and α 1A receptors respectively.
Контактные аллергены
Phenylephrine hydrochloride is an alpha-adrenergic
agonist, used as a mydriatic and decongestant in
eyedrops.
Профиль безопасности
Poison by ingestion, intraperitoneal, subcutaneous, intravenous,and intramuscular routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx.
L(-)-фенилэфрин гидрохлорид препаратная продукция и сырье
сырьё
препарат