2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine атрибут
Температура плавления: |
110 - 113°C |
Температура кипения: |
549.0±50.0 °C(Predicted) |
плотность: |
1.134±0.06 g/cm3(Predicted) |
температура хранения: |
2-8°C |
растворимость: |
ДМСО: > 2 мг/мл |
пка: |
5.97±0.10(Predicted) |
форма: |
пудра |
цвет: |
От белого до не совсем белого |
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine химические свойства, назначение, производство
Использование
GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.
Биохимия/физиол Действия
GANT61 blocks hedgehog pathway signaling by inhibiting the transcripional activity of Gli1 (IC50 = 5 μM). GANT 61 led to a regression of 22Rv1 human prostate tumor cell xenografts in nude mice.
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine препаратная продукция и сырье
сырьё
препарат
2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine поставщик
Global( 108)Suppliers
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