Хризин
Хризин атрибут
| Температура плавления: |
284-286 °C(lit.) |
| Температура кипения: |
357.45°C (rough estimate) |
| плотность: |
1.2693 (rough estimate) |
| показатель преломления: |
1.4872 (estimate) |
| температура хранения: |
Keep in dark place,Sealed in dry,Room Temperature |
| растворимость: |
ДМСО (Мало растворим), метанол (Мало растворим) |
| пка: |
6.50±0.40(Predicted) |
| форма: |
Кристаллический порошок |
| цвет: |
Желтый |
| Мерк: |
14,2256 |
| БРН: |
233276 |
| Стабильность:: |
Стабильный. Несовместим с сильными окислителями. |
| ИнЧИКей: |
RTIXKCRFFJGDFG-UHFFFAOYSA-N |
| LogP: |
3.520 |
| Справочник по базе данных CAS: |
480-40-0(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG: |
1 |
| FDA UNII: |
3CN01F5ZJ5 |
Хризин химические свойства, назначение, производство
Описание
Chrysin is a natural flavonoid with antioxidant, anti-inflammatory, and anticancer properties. It blocks COX-2 gene expression, PGE2 production, and hydroxyl radical formation in LPS-induced RAW 264.7 cells. Chrysin inhibits insulin-induced HIF-1α expression (~50% at 10 μM) in human prostate cancer DU145 cells and blocks DU145 xenograft-induced angiogenesis in vivo. In a mouse model of ischemia/reperfusion injury, chrysin decreased pro-inflammatory gene expression and oxidative stress, resulting in a reduction of infarct volume and neurological defects.
Химические свойства
beige powder or Pale yellow prismatic crystal (crystallized from methanol) with a melting point of 285°C. This substance is soluble in alkali hydroxide solution and acetone, slightly soluble in ether, ethanol and chloroform, insoluble in water.
Определение
ChEBI: Chrysin is a dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7. It has a role as an anti-inflammatory agent, an antineoplastic agent, an antioxidant, a hepatoprotective agent, an EC 2.7.11.18 (myosin-light-chain kinase) inhibitor and a plant metabolite. It is a dihydroxyflavone and a 7-hydroxyflavonol.
Источник
The main sources of chrysin are honey and propolis, of which the content of chrysin in honey is 5.3 mg/kg and that in propolis is 28 g/L. In addition, chrysin is also found in various vegetables, fruits, herbs, and even mushrooms. Another source of populin is an endophytic fungus Chaetomium globosum, which is related to Chaetomorpha media from India. In addition, chrysin exists in the form of glycosides in walnut, walnut skin, walnut flower and pericarp passion fruit, and in the form of 6-c-arabinoside-8-c-glucoside or glucuronic acid ester in Pinellia ternata.
Хризин препаратная продукция и сырье
сырьё
препарат
Хризин поставщик
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