Lysergic acid diethylamide химические свойства, назначение, производство
Описание
Lysergic acid diethylamide (LSD) is synthetically derived from
the fungus, Claviceps purpuria. Several isomers of this
compound exist, although only the D-isomer is considered
active. LSD was first synthesized by Albert Hofmann in 1938 in
a search for an analeptic drug. After finding its psychogenic
activity, it was marketed by Sandoz laboratories under the
name Delysid?. It was also reportedly used by the Central
Intelligence Agency as a tool for interrogation. Due to its
potential for ‘bad trips,’ ‘flashbacks,’ and potential risk for
brain injury, LSD was banned federally in 1966 and is
currently only used illicitly. LSD is chemically similar to other
naturally occurring lysergamides found in multiple species
of morning glory.
Химические свойства
crystalline solid
Использование
LSD is obtained by partial synthesis fromD-lysergic acid. It is also produced bymicrobial reaction of Claviceps paspali overthe hydroxylethylamide. It is a well-knownhallucinogen and a drug of abuse, listed asa controlled substance in the U.S. Code ofFederal Regulations (Title 21, Part 1308.11,1987). It is used as an antagonist to serotoninand in the study and treatment of mentaldisorders.
Определение
ChEBI: An ergoline alkaloid arising from formal condensation of lysergic acid with diethylamine.
Общее описание
Prismatic crystals (from benzene). Tasteless and odorless. A hallucinogen.
Профиль реактивности
An amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Угроза здоровью
LSD is a strong psychedelic agent. Theeffects in human are excitement, euphoria,hallucinations, and distorted perceptions.It alters the thinking process, producingillusions and loss of contact with reality.In humans, a dose (intramuscular)of 0.7–0.9 mg/kg or an oral dose of2.5–3.0 mg/kg may produce the effectsabove. Other symptoms may include nausea,vomiting, dilation of pupils, restlessness, andperipheral vascoconstriction. However, thereis no reported case of overdose death. In rabbits,somnolence, ataxia, and an increase inbody temperature were the symptoms notedat the LD50 (intravenous) doses at 0.3 mg/kg.
LD50 value, intravenous (mice): 46 mg/kg
LD50 value, subcutaneous (guinea pigs):16 mg/kg.
Пожароопасность
Flash point data for LSD are not available; however LSD is probably combustible.
Профиль безопасности
Poison by ingestion,
subcutaneous, intraperitoneal, and
intravenous routes. Mutation data reported.
Human systemic effects by ingestion and
intramuscular routes: euphoria,
hallucinations, distorted perceptions,
excitement, anorexia, nausea and vomiting.
An experimental teratogen. Other
experimental reproductive effects. Mutation
data reported. A much-abused hallucinogen.
A federally regulated substance. When
heated to decomposition it emits toxic
fumes of NOx
Экологическая судьба
LSD may exist in the air or soil. In the air, LSD may be
susceptible to photochemical reactions with subsequently induced radical analogs. Photolysis and oxidative degradation
may occur with an airborne half-life of 18 min. LSD’s pKa of 7.8
will have a meaningful percentage of the drug in the cationic
form allowing it to interact with soil.
Lysergic acid diethylamide препаратная продукция и сырье
сырьё
препарат