Lanreotide Acetate
127984-74-1
|
- CAS №
- 127984-74-1
- английское имя:
- Lanreotide Acetate
- Синонимы:
- Somatulina;LANREOTIDE ACETATE;Angiopeptin acetate;Lanreotide Acetate(acetate);Lanreotide Acetate USP/EP/BP;10-(4-aminobutyl)-19-[(2-amino-3-naphthalen-2-yl-propanoyl)a...;3-(2-Naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-threoninamide cyclic (2→7)-disulfide acetate;10-(4-aminobutyl)-19-[(2-amino-3-naphthalen-2-yl-propanoyl)amino]-N-(1 -carbamoyl-2-hydroxy-propyl)-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol -3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14, 17-pentazacycloicosane-4-carboxamide;10-(4-aminobutyl)-N-(1-amino-3-hydroxy-1-oxobutan-2-yl)-19-[(2-amino-3-naphthalen-2-ylpropanoyl)amino]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
- CBNumber:
- CB81260986
- Формула:
- C54H69N11O10S2
- молекулярный вес:
- 0
- MOL File:
- 127984-74-1.mol
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Lanreotide Acetate атрибут
Температура плавления: |
>165°C (dec.) |
температура хранения: |
-20°C |
растворимость: |
ДМСО (Мало растворим), метанол (Мало растворим) |
форма: |
пудра |
цвет: |
От белого до не совсем белого |
ИнЧИКей: |
PUDHBTGHUJUUFI-UHFFFAOYSA-N |
SMILES: |
S1CC(NC(=O)C(N)CC2=CC=C3C(=C2)C=CC=C3)C(=O)NC(CC2=CC=C(O)C=C2)C(=O)NC(CC2C3=C(NC=2)C=CC=C3)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(C(NC(C(=O)N)C(O)C)=O)CS1 |
Словарь онкологических терминов NCI: |
lanreotide acetate |
FDA UNII: |
IEU56G3J9C |
Словарь наркотиков NCI: |
lanreotide acetate |
безопасность
- Заявления о рисках и безопасности
- код информации об опасности(GHS)
Коды опасности |
Xn |
Заявления о рисках |
63 |
Заявления о безопасности |
36/37 |
WGK Германия |
3 |
символ(GHS) |
|
сигнальное слово |
Warning |
Заявление об опасности |
пароль |
Заявление об опасности |
Класс опасности |
категория |
сигнальное слово |
пиктограмма |
предупреждение |
H361 |
Предполагается, что данное вещество может отрицательно
повлиять на способность к деторождению или на
неродившегося ребенка. |
Репродуктивная токсичность |
Категория 2 |
Предупреждение |
|
P201, P202, P281, P308+P313, P405,P501 |
|
Внимание |
P281 |
Пользоваться надлежащим индивидуальным защитным
снаряжением. |
|
Lanreotide Acetate химические свойства, назначение, производство
Описание
Lanreotide acetate, an octapeptide somatostatin analog, reached its first
worldwide market in France for acromegaly when surgery or radiotherapy have
failed to restore normal growth hormone secretion. Lanreotide is a selective inhibitor of
growth hormone and reduces the secretion of growth hormone, thyrotropin, motilin and
pancreatic polypeptide in humans. Lanreotide has antiproliferative properties and is
reportedly in clinical trials for the prevention of restenosis following coronary artery
angioplasty, for diabetic retinopathy, and as a therapy for psoriasis. Its potential for
neuroendocrine tumors and hormone-responsive prostate cancer has also been
demonstrated.
Клиническое использование
Lanreotide is used in the treatment of acromegaly, due to both pituitary and non-pituitary growth hormone-secreting tumors, and the management of symptoms caused by neuroendocrine tumors, particularly carcinoid tumors and VIPomas. Lanreotide (as lanreotide acetate) is manufactured by Ipsen, and marketed under the trade name Somatuline. It is available in several countries, including the United Kingdom, Australia and Canada, and was approved for sale in the United States by the Food and Drug Administration (FDA) on August 30, 2007. Lanreotide acetate is available in two formulations: a sustained release formulation (sold under the trade name Somatuline LA) and an extended release formulation (UK trade name Somatuline Autogel, or Somatuline Depot in the U.S.). In the United States and Canada, lanreotide is only indicated for the treatment of acromegaly. In the United Kingdom, it is also indicated in the treatment of thyrotrophic adenoma, a rare tumor of the pituitary gland which secretes TSH. Interestingly, lanreotide also shows activity against non-endocrine tumors, and, along with other somatostatin analogues, is being studied as a possible general antitumor agent.
Lanreotide Acetate препаратная продукция и сырье
сырьё
препарат
Lanreotide Acetate поставщик
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