Дезоксихолевой кислоты химические свойства, назначение, производство
Описание
Deoxycholic acid
sodium salt, which is a secondary bile acid and the metabolite
of intestinal bacteria, provides a nonsurgical treatment to
significantly reduce submental fat in adults via injection directly
into moderate-to-severe fatty tissue below the neck. When
injected into fatty tissue, deoxycholic acid helps destroy fat
cells. Although deoxycholic acid has many applications
beyond human health, the application as a dyslipidemia drug
was licensed to Kythera from Los Angeles Biomedical Institute
at Harbor-UCLA Medical Center in 2007. Allergan acquired
Kythera recently in 2015.
Химические свойства
white powder
Использование
Deoxycholic acid has been used in a modified procedure to recover 40-80% of a protein from a 1 μg/mL solution. It forms complexes with fatty acid. Used as an emulsifying agent in food, a precursor in the synthesis of cortisone, and a gallbladder stimulant. It has been used to study assess how physiological concentrations of ursodeoxycholic acid (UDCA) vs. deoxycholic acid (DCA) affect barrier function in mouse intestinal tissue. Deoxycholic acid has been used in a study to assess a pH-Responsive Mechanism of a Deoxycholic Acid and Folate Co-Modified Chitosan Micelle under Cancerous Environment. It has also been used in a study to investigate dose-dependent anti-inflammatory effect of ursodeoxycholic acid in experimental colitis.
Общее описание
This [TM="Certified Spiking Solution" is suitable for use as starting material in the preparation of linearity standards, calibrators, and controls in LC-MS/MS and GC/MS bile acid testing methods. Deoxycholic acid (DCA), also known as deoxycholate and cholanoic acid is a secondary bile acid that aids in the absorption of fats in the intestine. Mass spectrometry-based analysis of DCA is routinely performed in clinical diagnostic testing applications including neonatal testing of inborn errors of bile acid synthesis and differentiating among types of familial intrahepatic cholestasis.
Профиль безопасности
Poison by
intraperitoneal route. Moderately toxic by
ingestion and intravenous routes.
Questionable carcinogen with experimental
tumorigenic data. Experimental
reproductive effects. Mutation data reported. When heated to decomposition it
emits acrid smoke and irritating fumes.
Методы очистки
Reflux the acid with CCl4 (50mL/g), filter, evaporate under vacuum at 25o, recrystallise the residue from acetone and dry it under vacuum at 155o [Trenner et al. J Am Chem Soc 76 1196 1954]. A solution of (cholic acid-free) material (100mL) in 500mL of hot EtOH is filtered, evaporate it to less than 500mL on a hot plate, and pour it into 1500mL of cold diethyl ether. The precipitate, filtered off by suction, is crystallised twice from 1-2 parts of absolute EtOH, to give an alcoholate, m 118-120o, which is dissolved in EtOH (100mL for 60g) and poured into boiling water. After boiling until free of the EtOH, the precipitate is filtered off, dried, ground and dried to constant weight in vacuo [Sobotka & Goldberg Biochem J 26 555 1932]. Deoxycholic acid is also freed from fatty acids and cholic acid by silica gel chromatography and elution with 0.5% acetic acid in ethyl acetate [Tang et al. J Am Chem Soc 107 4058 1985]. It can also be recrystallised from butanone. Its solubility in H2O at 15o is 0.24g/L, but in EtOH it is 22.07g/L. [Beilstein 10 IV 1608.]
Дезоксихолевой кислоты препаратная продукция и сырье
сырьё
препарат