ПРОПИЛЕНКАРБОНАТ химические свойства, назначение, производство
Химические свойства
Propylene carbonate is a clear, colorless, mobile liquid, with a faint
odor.
Использование
propylene carbonate is used in chemical reactions as a solvent, plasticizer, solubilizer, or dilutent. It is also used in the synthesis of solar cells as well as lithium ion batteries.
Методы производства
Propylene carbonate may be prepared by the reaction of sodium
bicarbonate with propylene chlorohydrin.
Общее описание
Propylene carbonate is a cyclic carbonate that is commonly used as a solvent and as a reactive intermediate in organic synthesis. It is being considered as a potential electrochemical solvent due to its low vapor pressure, high dielectric constant and high chemical stability.
Propylene carbonate can be synthesized from propylene oxide and CO2. Optically active form of propylene carbonate can be prepared from the reaction between CO2 and racemic epoxides. Decomposition of propylene carbonate on the graphite electrode in lithium batteries results in the formation of a lithium intercalated compound.
Фармацевтические приложения
Propylene carbonate is used mainly as a solvent in oral and topical
pharmaceutical formulations.
In topical applications, propylene carbonate has been used in
combination with propylene glycol as a solvent for corticosteroids.
The corticosteroid is dissolved in the solvent mixture to yield microdroplets that can then be dispersed in petrolatum.Propylene
carbonate has been used as a dispensing solvent in topical
preparations.
Propylene carbonate has also been used in hard gelatin capsules
as a nonvolatile, stabilizing, liquid carrier. For formulations with a
low dosage of active drug, a uniform drug content may be obtained
by dissolving the drug in propylene carbonate and then spraying
this solution on to a solid carrier such as compressible sugar; the
sugar may then be filled into hard gelatin capsules
Propylene carbonate may additionally be used as a solvent, at
room and elevated temperatures, for many cellulose-based polymers
and plasticizers. Propylene carbonate is also used in cosmetics.
Безопасность
Propylene Carbonate is listed in The Design for the Environment (DfE) Safer Chemistry Program by the EPA as a Solvent category and indicated by the Green circle, meaning the chemical has been verified to be of low concern for human and environmental health based on experimental and modeled data.
In animal studies, propylene carbonate was found to cause tissue necrosis after parenteral administration.
(mouse, oral): 20.7 g/kg
(mouse, SC): 15.8 g/kg
(rat, oral): 29 g/kg
(rat, SC): 11.1 g/kg
хранилище
Propylene carbonate and its aqueous solutions are stable but may
degrade in the presence of acids or bases, or upon heating;
Store in a well-closed container in a cool, dry place.
Методы очистки
It is manufactured by reaction of 1,2-propylene oxide with CO2 in the presence of a catalyst (quaternary ammonium halide). Contaminants include propylene oxide, carbon dioxide, 1,2-and 1,3-propanediols, allyl alcohol and ethylene carbonate. It can be purified by percolation through molecular sieves (Linde 5A, dried at 350o for 14hours under a stream of argon), followed by distillation under a vacuum. [Jasinski & Kirkland Anal Chem 39 163 1967.] It can be stored over molecular sieves under an inert gas atmosphere. When purified in this way it contains less than 2ppm of water. Activated alumina and dried CaO have also been used as drying agents prior to fractional distillation under reduced pressure. It has been dried with 3A molecular sieves and distilled under nitrogen in the presence of p-toluenesulfonic acid, then redistilled and the middle fraction collected. [Beilstein 19 III/IV 1564, 19/4 V 21.]
Несовместимости
Propylene carbonate hydrolyzes rapidly in the presence of strong
acids and bases, forming mainly propylene oxide and carbon
dioxide. Propylene carbonate can also react with primary and
secondary amines to yield carbamates.
Регуляторный статус
Included in the FDA Inactive Ingredients Database (topical
ointments). Included in the Canadian List of Acceptable Nonmedicinal
Ingredients.
ПРОПИЛЕНКАРБОНАТ препаратная продукция и сырье
сырьё
препарат