И 3330
|
136164-66-4
|
- CAS №
- 136164-66-4
- Химическое название:
- И 3330
- английское имя:
- E 3330
- Синонимы:
- E 3330;CS-1756;APX3330;APX 3330;E 3330;E-3330;E3330 (APX-3330);(2E)-3-(5-(2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl))-2-nonyl-2-propenoic acid;(2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid;Undecanoic acid, 2-[(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-, (2E)-;(2E)-2-[(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylidene]undecanoic acid E3330
- CBNumber:
- CB91355838
- Формула:
- C21H30O6
- молекулярный вес:
- 378.46
- MOL File:
- 136164-66-4.mol
|
И 3330 атрибут
| Температура плавления: |
56-57 °C |
| Температура кипения: |
542.2±50.0 °C(Predicted) |
| плотность: |
1.13±0.1 g/cm3(Predicted) |
| температура хранения: |
2-8°C |
| растворимость: |
ДМСО: >20 мг/мл |
| пка: |
4.29±0.19(Predicted) |
| форма: |
пудра |
| цвет: |
От красного до оранжевого |
| FDA UNII: |
11267UI968 |
безопасность
- Заявления о рисках и безопасности
- код информации об опасности(GHS)
И 3330 химические свойства, назначение, производство
Использование
E 3330 is a potent and selective APE1 inhibitor used in the treatment for age related macular degeneration.
Биохимия/физиол Действия
E3330 is a specific inhibitor of AP endonuclease 1 redox domain. E3330 inhibits APE-1 regulation of transcription factors, but does not affect Ape1 DNA repair activity. AP endonuclease 1 (APE1; also known as REF-1) is a multifunctional protein with dual functions in DNA repair and redox regulation of transcription factors. It is involved in apurinic/apyrimidinic endonuclease DNA base excision repair activity, in proofreading exonuclease activity, and in modulating DNA binding activity of several transcription factors including NF-κB, Egr-1, p53, AP-1, CREB, HIF-α, and members of the Pax family. APE1 is overexpressed in several human cancers, and disruption of APE1 function has detrimental effects on cancer cell viability. E3330 significantly reduces the growth of human pancreatic cancer cells in vitro and inhibits pancreatic cancer cell migration.
И 3330 препаратная продукция и сырье
сырьё
препарат
И 3330 поставщик
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