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ChemicalBook >> CAS DataBase List >> MI-3 (Menin-MLL Inhibitor)

MI-3 (Menin-MLL Inhibitor)

MI-3 (Menin-MLL Inhibitor) price.
  • $37 - $1260
  • Product name: MI-3 (Menin-MLL Inhibitor)
  • CAS: 1271738-59-0
  • MF: C18H25N5S2
  • MW: 375.55
  • EINECS:
  • MDL Number:MFCD28348362
  • Synonyms:MI-3;Menin-MLL inhibitor 3;Thieno[2,3-d]pyriMidine, 4-[4-(4,5-dihydro-5,5-diMethyl-2-thiazolyl)-1-piperazinyl]-6-(1-Methylethyl)-;4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine;MI-3 (Menin-MLL Inhibitor);4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine MI-3;5-dihydro-5;5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)
Price19 Properties Safety Information Description
19 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • Medical Isotopes, Inc.
  • TRC
Package
  • 500μg
  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product number3846AH
  • Product description4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine
  • Packaging1mg
  • Price$170
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3603
  • Product descriptionMI-3
  • Packaging5mg
  • Price$221
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3603
  • Product descriptionMI-3
  • Packaging10mg
  • Price$347
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3603
  • Product descriptionMI-3
  • Packaging50mg
  • Price$1040
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3603
  • Product descriptionMI-3
  • Packaging100mg
  • Price$1260
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number27214
  • Product descriptionMI-3
  • Packaging500μg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27214
  • Product descriptionMI-3
  • Packaging1mg
  • Price$65
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27214
  • Product descriptionMI-3
  • Packaging5mg
  • Price$231
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM151596
  • Product description4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine 98%
  • Packaging50mg
  • Price$590
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0772
  • Product descriptionMI-3 99.73%
  • Packaging5mg
  • Price$156
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0772
  • Product descriptionMI-3 99.73%
  • Packaging10mg
  • Price$252
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0772
  • Product descriptionMI-3 99.73%
  • Packaging50mg
  • Price$840
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0772
  • Product descriptionMI-3 99.73%
  • Packaging100mg
  • Price$1080
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004025
  • Product descriptionMI-3 98+%
  • Packaging5mg
  • Price$186
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004025
  • Product descriptionMI-3 98+%
  • Packaging10mg
  • Price$267
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004025
  • Product descriptionMI-3 98+%
  • Packaging50mg
  • Price$631
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3846AH 4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine 1mg $170 2021-12-16 Buy
ApexBio Technology A3603 MI-3 5mg $221 2021-12-16 Buy
ApexBio Technology A3603 MI-3 10mg $347 2021-12-16 Buy
ApexBio Technology A3603 MI-3 50mg $1040 2021-12-16 Buy
ApexBio Technology A3603 MI-3 100mg $1260 2021-12-16 Buy
Cayman Chemical 27214 MI-3 500μg $37 2024-03-01 Buy
Cayman Chemical 27214 MI-3 1mg $65 2024-03-01 Buy
Cayman Chemical 27214 MI-3 5mg $231 2024-03-01 Buy
Chemenu CM151596 4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine 98% 50mg $590 2021-12-16 Buy
ChemScene CS-0772 MI-3 99.73% 5mg $156 2021-12-16 Buy
ChemScene CS-0772 MI-3 99.73% 10mg $252 2021-12-16 Buy
ChemScene CS-0772 MI-3 99.73% 50mg $840 2021-12-16 Buy
ChemScene CS-0772 MI-3 99.73% 100mg $1080 2021-12-16 Buy
Crysdot CD31004025 MI-3 98+% 5mg $186 2021-12-16 Buy
Crysdot CD31004025 MI-3 98+% 10mg $267 2021-12-16 Buy
Crysdot CD31004025 MI-3 98+% 50mg $631 2021-12-16 Buy
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Properties

Boiling point :527.9±60.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : 8.33 mg/mL (22.18 mM; Need ultrasonic)
form :Powder
pka :9.59±0.40(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

MI-3 is an inhibitor of the interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC50 = 648 nM). MI-3 binds to menin (Kd = 201 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. It inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL (IC50 = 5 μM for both), as well as reduces colony formation and induces differentiation of MLL-AF9-transformed BMCs. MI-3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells.

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