N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
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- $45 - $1647
- Product name: N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
- CAS: 211311-95-4
- MF: C19H22N2O2S
- MW: 342.46
- EINECS:
- MDL Number:MFCD07364003
- Synonyms:N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;LY404187;N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonaMide;N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide;N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide;LY-404187 N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;CS-2739;100775
23 prices
Selected condition：
Brand
- AK Scientific
- Alichem
- American Custom Chemicals Corporation
- Cayman Chemical
- Crysdot
- CSNpharm
- Matrix Scientific
- Tocris
- TRC
- Usbiological
Package
- 10
- 5mg
- 1mg
- 50
- 10MG
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number0790AB
- Product descriptionN-(2-(4''-Cyano-[1,1''-biphenyl]-4-yl)propyl)propane-2-sulfonamide
- Packaging100mg
- Price$583
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number211311954
- Product descriptionN-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide
- Packaging100mg
- Price$426.6
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number211311954
- Product descriptionN-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide
- Packaging250mg
- Price$619.36
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number211311954
- Product descriptionN-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide
- Packaging1g
- Price$1595.8
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0019027
- Product descriptionLY-404187 95.00%
- Packaging10MG
- Price$240.45
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number28741
- Product descriptionLY404187
- Packaging5mg
- Price$110
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28741
- Product descriptionLY404187
- Packaging10mg
- Price$175
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28741
- Product descriptionLY404187
- Packaging25mg
- Price$352
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28741
- Product descriptionLY404187
- Packaging50mg
- Price$542
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD12096637
- Product descriptionN-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 97%
- Packaging100mg
- Price$391
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD12096637
- Product descriptionN-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 97%
- Packaging250mg
- Price$626
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD12096637
- Product descriptionN-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 97%
- Packaging1g
- Price$1565
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN22957
- Product descriptionLY404187
- Packaging5mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN22957
- Product descriptionLY404187
- Packaging25mg
- Price$335
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN22957
- Product descriptionLY404187
- Packaging50mg
- Price$636
- Updated2021-12-16
- Buy
- ManufacturerMatrix Scientific
- Product number090059
- Product descriptionN-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 95+%
- Packaging250mg
- Price$742
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 0790AB | N-(2-(4''-Cyano-[1,1''-biphenyl]-4-yl)propyl)propane-2-sulfonamide | 100mg | $583 | 2021-12-16 | Buy |
| Alichem | 211311954 | N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide | 100mg | $426.6 | 2021-12-16 | Buy |
| Alichem | 211311954 | N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide | 250mg | $619.36 | 2021-12-16 | Buy |
| Alichem | 211311954 | N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide | 1g | $1595.8 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0019027 | LY-404187 95.00% | 10MG | $240.45 | 2021-12-16 | Buy |
| Cayman Chemical | 28741 | LY404187 | 5mg | $110 | 2024-03-01 | Buy |
| Cayman Chemical | 28741 | LY404187 | 10mg | $175 | 2024-03-01 | Buy |
| Cayman Chemical | 28741 | LY404187 | 25mg | $352 | 2024-03-01 | Buy |
| Cayman Chemical | 28741 | LY404187 | 50mg | $542 | 2024-03-01 | Buy |
| Crysdot | CD12096637 | N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 97% | 100mg | $391 | 2021-12-16 | Buy |
| Crysdot | CD12096637 | N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 97% | 250mg | $626 | 2021-12-16 | Buy |
| Crysdot | CD12096637 | N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 97% | 1g | $1565 | 2021-12-16 | Buy |
| CSNpharm | CSN22957 | LY404187 | 5mg | $88 | 2021-12-16 | Buy |
| CSNpharm | CSN22957 | LY404187 | 25mg | $335 | 2021-12-16 | Buy |
| CSNpharm | CSN22957 | LY404187 | 50mg | $636 | 2021-12-16 | Buy |
| Matrix Scientific | 090059 | N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide 95+% | 250mg | $742 | 2021-12-16 | Buy |
Properties
Boiling point :519.0±60.0 °C(Predicted)
Density :1.19±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL
form :A solid
pka :11.24±0.40(Predicted)
color :White to off-white
Density :1.19±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL
form :A solid
pka :11.24±0.40(Predicted)
color :White to off-white
Safety Information
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Description
LY404187 is a benzothiadiazide positive allosteric modulator of AMPA receptors. It increases glutamate-induced activation of GluR1i, -2i, -2o, -3i, and -4i subunit-containing AMPA receptors with EC50 values of 5.65, 0.15, 1.44, 1.66, and 0.21 μM, respectively, in a calcium influx assay. LY404187 is selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 μM. LY404187 increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC50s = 1.3 and 1.2 μM, respectively) but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons. LY404187 prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA in mouse and rat, respectively, models of Parkinson’s disease when administered at a dose of 0.5 mg/kg per day.Related product price
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