4EGI-1
|
- $44 - $2839
- Product name: 4EGI-1
- CAS: 315706-13-9
- MF: C18H12Cl2N4O4S
- MW: 451.28
- EINECS:2017-001-1
- MDL Number:MFCD28142689
- Synonyms:4EGI-1;α-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid;eIF4E/eIF4G Interaction Inhibitor, 4EGI-1;4EGI-1, >=98%;alpha-[2-[4-(3,4-Dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitrobenzenepropanoic acid;2-((4-(3,4-Dichlorophenyl)thiazol-2(3H)-ylidene)hydrazono)-3-(2-nitrophenyl)propanoic acid;CS-1408;CS-1896
32 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 1mg
- 2mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- 1000mg
- ManufacturerAK Scientific
- Product number2171AH
- Product description4EGI-1
- Packaging10mg
- Price$336
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0013743
- Product description4EGI-1 95.00%
- Packaging5MG
- Price$498.61
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3696
- Product description4EGI-1
- Packaging10mM(in 1mL DMSO)
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3696
- Product description4EGI-1
- Packaging10mg
- Price$137
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3696
- Product description4EGI-1
- Packaging25mg
- Price$235
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60444
- Product description4EGI-1 ≥98%
- Packaging10mg
- Price$288
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181187
- Product description4EGI-1 >98%
- Packaging100mg
- Price$838.1
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181187
- Product description4EGI-1 >98%
- Packaging1000mg
- Price$2839
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBE177467
- Product description4EGI-1 NEW
- Packaging2mg
- Price$234
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBE177467
- Product description4EGI-1 NEW
- Packaging5mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBE177467
- Product description4EGI-1 NEW
- Packaging10mg
- Price$430
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15362
- Product description4EGI-1 ≥95%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15362
- Product description4EGI-1 ≥95%
- Packaging5mg
- Price$130
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15362
- Product description4EGI-1 ≥95%
- Packaging10mg
- Price$214
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15362
- Product description4EGI-1 ≥95%
- Packaging25mg
- Price$374
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM190479
- Product description2-((4-(3,4-Dichlorophenyl)thiazol-2(3H)-ylidene)hydrazono)-3-(2-nitrophenyl)propanoicacid 98%
- Packaging100mg
- Price$380
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2171AH | 4EGI-1 | 10mg | $336 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0013743 | 4EGI-1 95.00% | 5MG | $498.61 | 2021-12-16 | Buy |
| ApexBio Technology | B3696 | 4EGI-1 | 10mM(in 1mL DMSO) | $130 | 2021-12-16 | Buy |
| ApexBio Technology | B3696 | 4EGI-1 | 10mg | $137 | 2021-12-16 | Buy |
| ApexBio Technology | B3696 | 4EGI-1 | 25mg | $235 | 2021-12-16 | Buy |
| Arctom | CFN60444 | 4EGI-1 ≥98% | 10mg | $288 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181187 | 4EGI-1 >98% | 100mg | $838.1 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181187 | 4EGI-1 >98% | 1000mg | $2839 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BE177467 | 4EGI-1 NEW | 2mg | $234 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BE177467 | 4EGI-1 NEW | 5mg | $350 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BE177467 | 4EGI-1 NEW | 10mg | $430 | 2021-12-16 | Buy |
| Cayman Chemical | 15362 | 4EGI-1 ≥95% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 15362 | 4EGI-1 ≥95% | 5mg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 15362 | 4EGI-1 ≥95% | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 15362 | 4EGI-1 ≥95% | 25mg | $374 | 2024-03-01 | Buy |
| Chemenu | CM190479 | 2-((4-(3,4-Dichlorophenyl)thiazol-2(3H)-ylidene)hydrazono)-3-(2-nitrophenyl)propanoicacid 98% | 100mg | $380 | 2021-12-16 | Buy |
Properties
Boiling point :668.9±65.0 °C(Predicted)
Density :1.58±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥22.56 mg/mL in DMSO
form :Brown solid.
pka :0.89±0.41(Predicted)
color :Light yellow to khaki
Density :1.58±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥22.56 mg/mL in DMSO
form :Brown solid.
pka :0.89±0.41(Predicted)
color :Light yellow to khaki
Safety Information
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Description
In eukaryotes, a set of initiation factors (eIFs) interact with ribosomal subunits to initiate mRNA translation. A major step in initiation is the assembly of a large multiprotein complex that includes the cap-binding protein eIF4E and the multidomain adaptor protein eIF4G. 4EGI-1 is an inhibitor of the initiation of translation that blocks the interaction of eIF4G with eIF4E (KD = 25 μM). It directly binds eIF4E, competitively inhibiting an association with eIF4G that is necessary for cap-dependent translation. 4EGI-1 prevents the expression of oncogenic proteins in mammalian cancer cells, leading to apoptosis. Research with this inhibitor supports a role for normal eIF4E/eIF4G interaction in memory consolidation and excess interaction in autism spectrum disorders. 4EGI-1 also blocks translation in some viruses that do not require eIF4E or a cap structure for initiation.Related product price
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