DIFOPEIN
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- $503.48 - $573
- Product name: DIFOPEIN
- CAS: 396834-58-5
- MF: C273H424N76O89S6
- MW: 6387.13
- EINECS:
- MDL Number:MFCD06798321
- Synonyms:M.W. 6387.17 C273H424N76O89S6;DIFOPEIN
- American Custom Chemicals Corporation
- Usbiological
- 100ug
- 5MG
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberPRO0000351
- Product descriptionDIFOPEIN 95.00%
- Packaging5MG
- Price$503.48
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number255139
- Product descriptionDifopein
- Packaging100ug
- Price$573
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
American Custom Chemicals Corporation | PRO0000351 | DIFOPEIN 95.00% | 5MG | $503.48 | 2021-12-16 | Buy |
Usbiological | 255139 | Difopein | 100ug | $573 | 2021-12-16 | Buy |
Properties
Water Solubility :Soluble to 5 mg/ml in Water
Safety Information
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Description
Difopein is an inhibitor of 14-3-3 protein.
14-3-3 protein has been involved in a wide range of biologic processes such as signal transduction, vesicular transport, cell cycle control, DNA replication, DNA repair and apoptosis. 14-3-3 protein has been associated with tumor genesis. 14-3-3 protein correlates with reduced tumor cell apoptosis and abbreviated patient survival. Up-regulation of 14-3-3 protein provides a survival advantage to tumor cells. Inhibition of 14-3-3 protein might trigger apoptosis, inhibit growth of established tumors, suppress de novo tumor formation, and promise a novel therapeutic approach for glioma treatment [1].
In human glioma U251 and U87 cells, difopein resulted in apoptosis characteristics, such as nuclear fragmentation, DNA laddering fragment and appearance of membrane-enclosed apoptotic bodies. Difopein induced apoptosis in a time-dependent manner [1]. Difopein induced glioma cell apoptosis through down-regulating Bcl-2, up-regulating Bax and activating caspase-9 and caspase-3. In vivo, difopein effectively hindered proliferation and triggered apoptosis of tumor cells implanted into nude mice [1].
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