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ChemicalBook >> CAS DataBase List >> PF 3644022

PF 3644022

PF 3644022 price.
  • $160 - $2440
  • Product name: PF 3644022
  • CAS: 1276121-88-0
  • MF: C21H18N4OS
  • MW: 374.46
  • EINECS:
  • MDL Number:MFCD22683806
  • Synonyms:PF 3644022;(10R)-9,10,11,12-Tetrahydro-10-Methyl-3-(6-Methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one;MK2 INHIBITOR;8H-[1,4]Diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one, 9,10,11,12-tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-, (10R)-;(R)-10-Methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one;MAPKAP kinase 2,monocytic,lipopolysaccharide,IL-6,TNFα,safety,Anti-inflammatory,PF3644022,orally,PRAK,efficacious,inhibit,PF-3644022,Mitogen-activated protein kinase activated protein kinase 2,p38 MAPK,Inhibitor,MK3,MAP kinase activated protein kinase 2,MAPKAPK2 (MK2),MAPK activated protein kinase 2,PF 3644022;(R)-10-Methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one
Price15 Properties Safety Information Description
15 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • ChemScene
  • Crysdot
  • CSNpharm
  • Medical Isotopes, Inc.
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 1mg
  • 2.5mg
  • 5mg
  • 10MG
  • 100MG
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001429
  • Product descriptionPF-3644022 98.00%
  • Packaging10MG
  • Price$785.4
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001429
  • Product descriptionPF-3644022 98.00%
  • Packaging100MG
  • Price$2240.7
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5549
  • Product descriptionPF-3644022
  • Packaging10mg
  • Price$448
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0028456
  • Product descriptionPF-3644022 >99.0%
  • Packaging1mg
  • Price$198
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0028456
  • Product descriptionPF-3644022 >99.0%
  • Packaging5mg
  • Price$595
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0028456
  • Product descriptionPF-3644022 >99.0%
  • Packaging10mg
  • Price$1050
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004012
  • Product descriptionPF-3644022 95+%
  • Packaging10mg
  • Price$1167
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004012
  • Product descriptionPF-3644022 95+%
  • Packaging5mg
  • Price$778
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN15896
  • Product descriptionPF-3644022
  • Packaging5mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN15896
  • Product descriptionPF-3644022
  • Packaging10mg
  • Price$270
  • Updated2021-12-16
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number52702
  • Product descriptionPF-3644022
  • Packaging100mg
  • Price$2440
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number4279
  • Product descriptionPF3644022 ≥98%(HPLC)
  • Packaging10
  • Price$315
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberP293825
  • Product descriptionPF-3644022
  • Packaging2.5mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberP293825
  • Product descriptionPF-3644022
  • Packaging10mg
  • Price$675
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number019315
  • Product descriptionPF-3644022
  • Packaging10mg
  • Price$502
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation KIN0001429 PF-3644022 98.00% 10MG $785.4 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001429 PF-3644022 98.00% 100MG $2240.7 2021-12-16 Buy
ApexBio Technology B5549 PF-3644022 10mg $448 2021-12-16 Buy
ChemScene CS-0028456 PF-3644022 >99.0% 1mg $198 2021-12-16 Buy
ChemScene CS-0028456 PF-3644022 >99.0% 5mg $595 2021-12-16 Buy
ChemScene CS-0028456 PF-3644022 >99.0% 10mg $1050 2021-12-16 Buy
Crysdot CD31004012 PF-3644022 95+% 10mg $1167 2021-12-16 Buy
Crysdot CD31004012 PF-3644022 95+% 5mg $778 2021-12-16 Buy
CSNpharm CSN15896 PF-3644022 5mg $160 2021-12-16 Buy
CSNpharm CSN15896 PF-3644022 10mg $270 2021-12-16 Buy
Medical Isotopes, Inc. 52702 PF-3644022 100mg $2440 2021-12-16 Buy
Tocris 4279 PF3644022 ≥98%(HPLC) 10 $315 2021-12-16 Buy
TRC P293825 PF-3644022 2.5mg $180 2021-12-16 Buy
TRC P293825 PF-3644022 10mg $675 2021-12-16 Buy
Usbiological 019315 PF-3644022 10mg $502 2021-12-16 Buy

Properties

Melting point :>180°C (dec.)
Boiling point :703.3±60.0 °C(Predicted)
Density :1.298±0.06 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :13.51±0.40(Predicted)
color :Off-White to Yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PF-3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF-3644022 is a benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation.

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