PF 477736
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- $41 - $2440
- Product name: PF 477736
- CAS: 952021-60-2
- MF: C22H25N7O2
- MW: 419.49
- EINECS:
- MDL Number:MFCD16038847
- Synonyms:PF 477736;PF-00477736;PF-736;(αR)-α-AMino-N-[5,6-dihydro-2-(1-Methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]cyclohexaneacetaMide;PF 477736(PF-0044736);(2R)-2-aMino-2-cyclohexyl-N-[2-(1-Methyl-1H-pyrazol-4-yl)-9-oxo-3,10,11-triazatricyclo[6.4.1.0^{4,13}]trideca-1,4(13),5,7,11-pentaen-6-yl]acetaMide;PF0044736;PF-0044736
28 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 10mg
- 25MG
- 50mg
- 50
- 250mg
- 10mM(in 1mL DMSO)
- 100mg
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3537-M010
- Product descriptionPF-0477736 ≥95%(HPLC)
- Packaging10mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1174
- Product descriptionPF0477736
- Packaging10mg
- Price$230
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA464575
- Product descriptionPf-477736 98+%
- Packaging1mg
- Price$41
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA464575
- Product descriptionPf-477736 98+%
- Packaging5mg
- Price$69
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA464575
- Product descriptionPf-477736 98+%
- Packaging10mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA464575
- Product descriptionPf-477736 98+%
- Packaging50mg
- Price$403
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA464575
- Product descriptionPf-477736 98+%
- Packaging100mg
- Price$557
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000184
- Product descriptionPF-477736 95.00%
- Packaging10MG
- Price$785.4
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000184
- Product descriptionPF-477736 95.00%
- Packaging25MG
- Price$1390
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000184
- Product descriptionPF-477736 95.00%
- Packaging100MG
- Price$2240.7
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1437
- Product descriptionPF-477736
- Packaging5mg
- Price$103
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1437
- Product descriptionPF-477736
- Packaging10mg
- Price$147
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1437
- Product descriptionPF-477736
- Packaging10mM(in 1mL DMSO)
- Price$175
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1437
- Product descriptionPF-477736
- Packaging50mg
- Price$469
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1379
- Product descriptionPF477736-PF00477736 98%
- Packaging25mg
- Price$352
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17859
- Product descriptionPF-477736 ≥98%
- Packaging5mg
- Price$106
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3537-M010 | PF-0477736 ≥95%(HPLC) | 10mg | $120 | 2021-12-16 | Buy |
| AK Scientific | SYN1174 | PF0477736 | 10mg | $230 | 2021-12-16 | Buy |
| Ambeed | A464575 | Pf-477736 98+% | 1mg | $41 | 2021-12-16 | Buy |
| Ambeed | A464575 | Pf-477736 98+% | 5mg | $69 | 2021-12-16 | Buy |
| Ambeed | A464575 | Pf-477736 98+% | 10mg | $120 | 2021-12-16 | Buy |
| Ambeed | A464575 | Pf-477736 98+% | 50mg | $403 | 2021-12-16 | Buy |
| Ambeed | A464575 | Pf-477736 98+% | 100mg | $557 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000184 | PF-477736 95.00% | 10MG | $785.4 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000184 | PF-477736 95.00% | 25MG | $1390 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000184 | PF-477736 95.00% | 100MG | $2240.7 | 2021-12-16 | Buy |
| ApexBio Technology | B1437 | PF-477736 | 5mg | $103 | 2021-12-16 | Buy |
| ApexBio Technology | B1437 | PF-477736 | 10mg | $147 | 2021-12-16 | Buy |
| ApexBio Technology | B1437 | PF-477736 | 10mM(in 1mL DMSO) | $175 | 2021-12-16 | Buy |
| ApexBio Technology | B1437 | PF-477736 | 50mg | $469 | 2021-12-16 | Buy |
| Axon Medchem | Axon1379 | PF477736-PF00477736 98% | 25mg | $352 | 2021-12-16 | Buy |
| Cayman Chemical | 17859 | PF-477736 ≥98% | 5mg | $106 | 2024-03-01 | Buy |
Properties
Density :1.56
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL
form :powder
pka :11.79±0.20(Predicted)
color :yellow
InChIKey :NDEXUOWTGYUVGA-LJQANCHMSA-N
storage temp. :2-8°C
solubility :DMSO: ≥20mg/mL
form :powder
pka :11.79±0.20(Predicted)
color :yellow
InChIKey :NDEXUOWTGYUVGA-LJQANCHMSA-N
Safety Information
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Description
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. PF-477736 is an ATP-competitive inhibitor of Chk1 with a Ki value of 0.49 nM that demonstrates 100-fold selectivity over Chk2. When used in combination with various chemotherapeutics, PF-477736 abrogates DNA damage-induced cell cycle arrest, potentiating the antiproliferative effects of these compounds in tumor cell lines and xenografts.Related product price
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$70-3728.1 - 1469284-79-4
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