RVX-208
- $44 - $1423
- Product name: RVX-208
- CAS: 1044870-39-4
- MF: C20H22N2O5
- MW: 370.4
- EINECS:
- MDL Number:MFCD18633270
- Synonyms:2-(4-(2-hydroxyethoxy)-3,5-diMethylphenyl)-5,7-diMethoxyquinazolin-4(3H)-one;RVX-000222;4(3H)-Quinazolinone, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-;2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinazolinone RVX-208;RVX-208;Apabetalone;Apabetalone-RVX-208;RVX-208(RVX 000222)
28 prices
Selected condition:
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Biosynth Carbosynth
- BroadPharm
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 1mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberZ3839
- Product descriptionRVX-208
- Packaging50mg
- Price$522.5
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0387744
- Product description2-(4-(2-HYDROXYETHOXY)-3,5-DIMETHYLPHENYL)-5,7-DIMETHOXYQUINAZOLIN-4(3H)-ONE 95.00%
- Packaging5MG
- Price$497.28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1499
- Product descriptionRVX-208
- Packaging5mg
- Price$68
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545916
- Product descriptionRVX-208 >98%
- Packaging5mg
- Price$187
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb545916
- Product descriptionRVX-208 >98%
- Packaging25mg
- Price$508.3
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFR137715
- Product descriptionRVX 208
- Packaging10mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFR137715
- Product descriptionRVX 208
- Packaging50mg
- Price$437.5
- Updated2021-12-16
- Buy
- ManufacturerBroadPharm
- Product numberBP-23380
- Product descriptionRVX-208 98%
- Packaging10mg
- Price$280
- Updated2021-12-16
- Buy
- ManufacturerBroadPharm
- Product numberBP-23380
- Product descriptionRVX-208 98%
- Packaging25mg
- Price$490
- Updated2021-12-16
- Buy
- ManufacturerBroadPharm
- Product numberBP-23380
- Product descriptionRVX-208 98%
- Packaging50mg
- Price$780
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16424
- Product descriptionRVX-208 ≥98%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16424
- Product descriptionRVX-208 ≥98%
- Packaging5mg
- Price$109
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16424
- Product descriptionRVX-208 ≥98%
- Packaging10mg
- Price$193
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16424
- Product descriptionRVX-208 ≥98%
- Packaging25mg
- Price$404
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM116104
- Product description2-[4-(2-Hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one 95%
- Packaging1g
- Price$402
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3239
- Product descriptionApabetalone 99.86%
- Packaging5mg
- Price$82
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | Z3839 | RVX-208 | 50mg | $522.5 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | CHM0387744 | 2-(4-(2-HYDROXYETHOXY)-3,5-DIMETHYLPHENYL)-5,7-DIMETHOXYQUINAZOLIN-4(3H)-ONE 95.00% | 5MG | $497.28 | 2021-12-16 | Buy |
ApexBio Technology | B1499 | RVX-208 | 5mg | $68 | 2021-12-16 | Buy |
Biorbyt Ltd | orb545916 | RVX-208 >98% | 5mg | $187 | 2021-12-16 | Buy |
Biorbyt Ltd | orb545916 | RVX-208 >98% | 25mg | $508.3 | 2021-12-16 | Buy |
Biosynth Carbosynth | FR137715 | RVX 208 | 10mg | $125 | 2021-12-16 | Buy |
Biosynth Carbosynth | FR137715 | RVX 208 | 50mg | $437.5 | 2021-12-16 | Buy |
BroadPharm | BP-23380 | RVX-208 98% | 10mg | $280 | 2021-12-16 | Buy |
BroadPharm | BP-23380 | RVX-208 98% | 25mg | $490 | 2021-12-16 | Buy |
BroadPharm | BP-23380 | RVX-208 98% | 50mg | $780 | 2021-12-16 | Buy |
Cayman Chemical | 16424 | RVX-208 ≥98% | 1mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 16424 | RVX-208 ≥98% | 5mg | $109 | 2024-03-01 | Buy |
Cayman Chemical | 16424 | RVX-208 ≥98% | 10mg | $193 | 2024-03-01 | Buy |
Cayman Chemical | 16424 | RVX-208 ≥98% | 25mg | $404 | 2024-03-01 | Buy |
Chemenu | CM116104 | 2-[4-(2-Hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one 95% | 1g | $402 | 2021-12-16 | Buy |
ChemScene | CS-3239 | Apabetalone 99.86% | 5mg | $82 | 2021-12-16 | Buy |
Properties
Boiling point :594.2±60.0 °C(Predicted)
Density :1.28±0.1 g/cm3(Predicted)
storage temp. :-20°C (des.)
solubility :Soluble in DMSO (up to 75 mg/ml) or in Ethanol (up to 4 mg/ml).
form :solid
pka :14.21±0.10(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Density :1.28±0.1 g/cm3(Predicted)
storage temp. :-20°C (des.)
solubility :Soluble in DMSO (up to 75 mg/ml) or in Ethanol (up to 4 mg/ml).
form :solid
pka :14.21±0.10(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety Information
Symbol(GHS): | |||||||||||||||
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Signal word: | Warning | ||||||||||||||
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Description
The bromodomain and extra terminal (BET) proteins interact with acetylated lysine-containing sequences on target proteins via their bromodomains, commonly altering gene transcription. The human BET proteins contain two bromodomains, the first (BD1) being closer to the N-terminus than the second (BD2). RVX-208 is a selective antagonist of BET bromodomains, binding with 10-100-fold higher affinity for BD2 (IC50 = 0.04-0.28 μM) over BD1 (IC50 = 1.8-3.1 μM). RVX-208 causes the selective release of BET proteins from chromatin in cells. It interferes with the BET protein BRD4, resulting in an increased expression of apolipoprotein (Apo) A1 in cells, mice, monkeys, and humans. RVX-208 also reduces atherosclerosis in hyperlipidemic ApoE-deficient mice.More related product prices
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