1-(1-Benzylpiperidin-4-yl)pyrrolidin-2-one synthesis
- Product Name:1-(1-Benzylpiperidin-4-yl)pyrrolidin-2-one
- CAS Number:340962-88-1
- Molecular formula:C16H22N2O
- Molecular Weight:258.36
Yield:340962-88-1 94.6%
Reaction Conditions:
Stage #1: 1-phenylmethyl-4-piperidone;ethyl γ-aminobutyrate hydrochloridewith sodium tris(acetoxy)borohydride for 1.5 h;
Stage #2: with triethylamine at 20 - 60; for 21 h;Solvent;Temperature;Time;
References:
Mapes, Christopher M.;Mani, Neelakandha S. [Organic Process Research and Development,2007,vol. 11,# 3,p. 482 - 486] Location in patent:supporting information
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