ChemicalBook CAS DataBase List 1-(4-Methoxybenzyl)-pyrrolidin-2-one

1-(4-Methoxybenzyl)-pyrrolidin-2-one synthesis

7synthesis methods

Product Name:1-(4-Methoxybenzyl)-pyrrolidin-2-one
CAS Number:60737-65-7
Molecular formula:C12H15NO2
Molecular Weight:205.25

616-45-5 Synthesis

616-45-5
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$14.00/25g

2746-25-0
173 suppliers
$27.57/250mgs:

60737-65-7
15 suppliers
$45.00/2.5mg

Yield:60737-65-7 89%

Reaction Conditions:

with sodium hydride in tetrahydrofuran;hexane; for 24.5 h;Cooling;

Steps:

3.2.10. 1-(2-Bromo-4,5-dimethoxybenzyl)pyrrolidin-2-one (12)

General procedure: To NaH (56.43 mg, 2.35 mmol) in a balloon (50 mL), washed with hexane, was added cold THF solution (0 C) of 2-pirrolidone (181.94 mg, 2.14 mmol) in THF (20 mL). The mixture was stirred for 30 min and then tetrabromide 5 (500 mg, 1.07 mmol) was added to the mixture. After the mixture was stirred at the sametemperature for 30 min more, the cold bath was removed and the mixture was additionally stirred for 24 h.After the removal of solvent from the reaction mixture under vacuum, cold solution (1%, 0 C, 15 mL) of NaOHwas slowly added to the resultant mixture. The new mixture was extracted with ethyl acetate (EtOAc) (2 20 mL). After the combined extracts were washed with water (20 mL) and dried over Na2SO4 , the solvent wasremoved under vacuum and compound 6 (0.4 g, 80%, white amorphous solid) was yielded

References:

Rezai, Mohsen;Bayrak, ?etin;Taslimi, Parham;Gül?in, Ilhami;Menzek, Abdullah [Turkish Journal of Chemistry,2018,vol. 42,# 3,p. 808 - 825]

616-45-5 Synthesis

616-45-5
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$14.00/25g

824-94-2 Synthesis