1-benzyl-4-(bromomethyl)-1H-1,2,3-triazole synthesis
- Product Name:1-benzyl-4-(bromomethyl)-1H-1,2,3-triazole
- CAS Number:70380-30-2
- Molecular formula:C10H10BrN3
- Molecular Weight:252.11
106-96-7
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622-79-7
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70380-30-2
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Yield:70380-30-2 97%
Reaction Conditions:
with Cu(II) nanoparticles supported on graphene quantum dots modified with nano-NiFe2O4 in lithium hydroxide monohydrate at 60; for 0.2 h;Green chemistry;
Steps:
Synthetic typical manner for 1,2,3-triazoles 3a-3f
General procedure: Cu(II)/GQDs/NiFe2O4 catalyst [0.05 g, 0.047 mmol Cu(II)] was added to a solution comprising aryl azide (1.1 mmol), terminal alkyne (1.0 mmol) in 3 cm3 water under continuous stirring for 10-30 min at 60 °C. The proceed of the reaction was controlled using TLC (thin layer chromatography), whenever the reaction was completed, the reaction mixture was diluted with ethyl acetate and the nano-catalyst was isolated with the aid of a magnet, washed with acetone and then dried on a night to be ready to react again. The organic layer was dried over anhydrate sodium sulfate and after that, evaporated to separate the solvent. The remaining part was recrystallized in ethanol to provide corresponding triazole derivatives. The products were recognized by their melting points, 13C NMR and 1H NMR spectroscopy. The selected spectral data of some synthesized products have been included in Supplementary Material.
References:
Deilam, Razieh;Moeinpour, Farid;Mohseni-Shahri, Fatemeh S. [Monatshefte fur Chemie,2020]
28798-81-4
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70380-30-2
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100-39-0
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70380-30-2
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622-79-7
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70380-30-2
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100-44-7
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$13.50/250G
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