1-BOC-4-(2-AMINO-4-PYRIDINYL)-PIPERAZINE synthesis
- Product Name:1-BOC-4-(2-AMINO-4-PYRIDINYL)-PIPERAZINE
- CAS Number:571189-23-6
- Molecular formula:C14H22N4O2
- Molecular Weight:278.35
19798-80-2
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Yield:571189-23-6 223 mg
Reaction Conditions:
in N,N-dimethyl acetamide at 190; for 0.166667 h;
Steps:
19.1 Step 1: preparation of tert-butyl 4-(2-amino-4-pyridyl)piperazine-1-carboxylate (compound 19b)
A mixture of 4-chloropyridin-2-amine (compound 19a, CAS: 19798-80-2, Vendor: Aldrich, 129 mg, 1.00 mmol) and te rt- butyl piperazine- 1-carboxy late (CAS: 57260-71-6, Vendor: Accela ChemBio Inc, 186 mg, 1.00 mmol) in N,N-dimethylacetamide (3 mL) was heated at 190 °C for 10 minutes. After the reaction mixture was cooled down, the solid was collected by filtration to give compound 19b (223 mg) as a grey solid. MS: calc'd 279 (MH+), measured 279 (MH+).
References:
WO2019/238629,2019,A1 Location in patent:Page/Page column 39-40
84249-14-9
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$6.00/1g
57260-71-6
735 suppliers
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571189-23-6
33 suppliers
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57260-71-6
735 suppliers
$5.00/5g
571189-23-6
33 suppliers
inquiry