![](/CAS/GIF/142253-56-3.gif)
1-Boc-Azetidine-3-yl-methanol synthesis
- Product Name:1-Boc-Azetidine-3-yl-methanol
- CAS Number:142253-56-3
- Molecular formula:C9H17NO3
- Molecular Weight:187.24
![1-N-Boc-3-Azetidinecarboxylic acid](/CAS/20180808/GIF/142253-55-2.gif)
142253-55-2
315 suppliers
$6.00/1g
![1-Boc-Azetidine-3-yl-methanol](/CAS/GIF/142253-56-3.gif)
142253-56-3
242 suppliers
$6.00/1g
Yield:142253-56-3 100%
Reaction Conditions:
with borane-THF at -78 - 20; for 2.5 h;Inert atmosphere;
Steps:
1 tert-butyl 3-(hydroxymethyl)azetidine-1-carboxylate(1.2)
To a stirring solutionof BH3/THF (285 ml)at -78°C was added 1-(tert butoxycarbonyl)azetidine-3-carboxylic acid (22.53 g, 112 mmol) in portions under a N2atmosphere, and the reaction was stirredfor 30 min. The reaction was then warmedto rt and stirred for 2 hr. The reaction mixturewas poured into ice (500 ml), and extractedwith EA (3 x300 ml). The combinedorganic layers were washed with brine (3 x 100 ml), dried (Na2S04), and filtered. The filtrate was concentrated under reduced pressureto yield compound1.2 as 5 clear oil (20.9 g, 100%). MS: m/z calcd for C9H17N03 187.1, found [M-H] 186.1.
References:
WO2014/165075,2014,A1 Location in patent:Page/Page column 45
![Methyl 1-Boc-azetidine-3-carboxylate](/CAS/GIF/610791-05-4.gif)
610791-05-4
153 suppliers
$5.00/250mg
![1-Boc-Azetidine-3-yl-methanol](/CAS/GIF/142253-56-3.gif)
142253-56-3
242 suppliers
$6.00/1g
![1-Azetidinecarboxylic acid, 3-methylene-, 1,1-dimethylethyl ester](/CAS/GIF/934664-41-2.gif)
934664-41-2
107 suppliers
$20.00/1g
![1-Boc-Azetidine-3-yl-methanol](/CAS/GIF/142253-56-3.gif)
142253-56-3
242 suppliers
$6.00/1g
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
824 suppliers
$13.50/25G
![(AZETIDIN-3-YL)METHANOL](/CAS/GIF/95849-02-8.gif)
95849-02-8
70 suppliers
$17.00/100mg
![1-Boc-Azetidine-3-yl-methanol](/CAS/GIF/142253-56-3.gif)
142253-56-3
242 suppliers
$6.00/1g
![1-(DIPHENYLMETHYL)-3-(HYDROXYMETHYL)AZETIDINE](/CAS/GIF/72351-36-1.gif)
72351-36-1
82 suppliers
$45.00/250mg
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
824 suppliers
$13.50/25G
![1-Boc-Azetidine-3-yl-methanol](/CAS/GIF/142253-56-3.gif)
142253-56-3
242 suppliers
$6.00/1g