![](/CAS/GIF/610791-05-4.gif)
Methyl 1-Boc-azetidine-3-carboxylate synthesis
- Product Name:Methyl 1-Boc-azetidine-3-carboxylate
- CAS Number:610791-05-4
- Molecular formula:C10H17NO4
- Molecular Weight:215.25
![1-N-Boc-3-Azetidinecarboxylic acid](/CAS/20180808/GIF/142253-55-2.gif)
142253-55-2
318 suppliers
$6.00/1g
![(TRIMETHYLSILYL)DIAZOMETHANE](/CAS/GIF/18107-18-1.gif)
18107-18-1
207 suppliers
$33.00/5g
![Methyl 1-Boc-azetidine-3-carboxylate](/CAS/GIF/610791-05-4.gif)
610791-05-4
151 suppliers
$5.00/250mg
Yield:610791-05-4 100%
Reaction Conditions:
in methanol;
Steps:
84.a
(a) 1-tert-Butyl 3-methyI azetidine-l,3-dicarboxylate; 1-(ter^Butoxycarbonyl)azetidine-3-carboxylic acid (2.42 g, 12.0 mmol) was dissolved in MeOH (30 mL) and TM5CHN2 (30.1 ml, 60.1 mmol) was added drop- wise at room temperature (reaction became warm and gas was evolved). TM5CHN2 was added until a persistent yellow color was produced indicating excess reagent. AcOH was added drop- wise to quench the excess TM5CHN2 and then the reaction mixture was concentrated under reduced pressure and azeotroped with toluene (3 x 20 mL) to remove any trace MeOH and AcOH. The crude material was used without any further purification assuming 100 % yield. 1H NMR (400 MHz, CDCl3): 6 1.44 (9H, s), 3.29-3.39 (1H, m), 3.75 (3H, s), 4.07-4.13 (4H, m).
References:
WO2006/73361,2006,A1 Location in patent:Page/Page column 171
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
737 suppliers
$9.00/25ml
![1-N-Boc-3-Azetidinecarboxylic acid](/CAS/20180808/GIF/142253-55-2.gif)
142253-55-2
318 suppliers
$6.00/1g
![Methyl 1-Boc-azetidine-3-carboxylate](/CAS/GIF/610791-05-4.gif)
610791-05-4
151 suppliers
$5.00/250mg
![1-N-Boc-3-Azetidinecarboxylic acid](/CAS/20180808/GIF/142253-55-2.gif)
142253-55-2
318 suppliers
$6.00/1g
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
341 suppliers
$15.00/10g
![Methyl 1-Boc-azetidine-3-carboxylate](/CAS/GIF/610791-05-4.gif)
610791-05-4
151 suppliers
$5.00/250mg
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
820 suppliers
$13.50/25G
![azetidine-3-carboxylic acid methyl ester](/CAS/GIF/343238-58-4.gif)
343238-58-4
47 suppliers
inquiry
![Methyl 1-Boc-azetidine-3-carboxylate](/CAS/GIF/610791-05-4.gif)
610791-05-4
151 suppliers
$5.00/250mg
![3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE](/CAS/GIF/100202-39-9.gif)
100202-39-9
187 suppliers
$7.00/1g
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
820 suppliers
$13.50/25G
![Methyl 1-Boc-azetidine-3-carboxylate](/CAS/GIF/610791-05-4.gif)
610791-05-4
151 suppliers
$5.00/250mg