ChemicalBook CAS DataBase List Methyl 1-Boc-azetidine-3-carboxylate

Methyl 1-Boc-azetidine-3-carboxylate synthesis

6synthesis methods

Product Name:Methyl 1-Boc-azetidine-3-carboxylate
CAS Number:610791-05-4
Molecular formula:C10H17NO4
Molecular Weight:215.25

142253-55-2 Synthesis

142253-55-2
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$6.00/1g

18107-18-1
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$33.00/5g

610791-05-4
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$5.00/250mg

Yield:610791-05-4 100%

Reaction Conditions:

in methanol;

Steps:

84.a

(a) 1-tert-Butyl 3-methyI azetidine-l,3-dicarboxylate; 1-(ter^Butoxycarbonyl)azetidine-3-carboxylic acid (2.42 g, 12.0 mmol) was dissolved in MeOH (30 mL) and TM5CHN₂ (30.1 ml, 60.1 mmol) was added drop- wise at room temperature (reaction became warm and gas was evolved). TM5CHN₂ was added until a persistent yellow color was produced indicating excess reagent. AcOH was added drop- wise to quench the excess TM5CHN₂ and then the reaction mixture was concentrated under reduced pressure and azeotroped with toluene (3 x 20 mL) to remove any trace MeOH and AcOH. The crude material was used without any further purification assuming 100 % yield. ¹H NMR (400 MHz, CDCl₃): 6 1.44 (9H, s), 3.29-3.39 (1H, m), 3.75 (3H, s), 4.07-4.13 (4H, m).

References:

WO2006/73361,2006,A1 Location in patent:Page/Page column 171

67-56-1 Synthesis