1-Ethylpyrazole synthesis
- Product Name:1-Ethylpyrazole
- CAS Number:2817-71-2
- Molecular formula:C5H8N2
- Molecular Weight:96.13
Yield:-
Reaction Conditions:
Stage #1:NH-pyrazole with potassium hydroxide in dimethyl sulfoxide at 80; for 0.5 h;
Stage #2:2-bromoethanol in dimethyl sulfoxide
Steps:
1 Test one:
3.40 g (0.05 mol) of pyrazoleAnd 2.8g (0.05mol) powdered KOH were added to a 100mL three-necked flask,Add 10mLDMSO as a solvent, the mixture was stirred at 80 for 30min,Then 6.25 g (0.05 mol) of 2-bromoethanol was added (added to the flask in 30 mL intervals, three times)Continue stirring for 20 ~ 30h, cooled to room temperature,After filtration, 20 mL of chloroform was added and the solution was washed with water (5 × 20 mL)Rotary drying to give a colorless transparent liquid 1-ethylpyrazole (yield: 60 ~ 70%).
References:
Henan University;Ren Tiegang;Wang Tengfei;Ma Yuan;Zhang Jingshun;Zhang Jinglai;Wang Li CN107501181, 2017, A Location in patent:Paragraph 0016; 0018
