1-METHOXY-4-(METHYLTHIO)BENZENE synthesis
- Product Name:1-METHOXY-4-(METHYLTHIO)BENZENE
- CAS Number:1879-16-9
- Molecular formula:C8H10OS
- Molecular Weight:154.23
624-92-0
314 suppliers
$20.62/5 mL
696-62-8
343 suppliers
$5.00/1g
1879-16-9
118 suppliers
$10.00/1g
Yield:1879-16-9 78%
Reaction Conditions:
with tetrabutylammomium bromide;copper(II) acetate monohydrate;potassium hydroxide in water at 100; for 12 h;Catalytic behavior;Sealed tube;Reagent/catalyst;Temperature;
Steps:
(Het)aryl Methyl Sulfides; General Procedure
General procedure: A 25-mL sealable tube was charged with the appropriate aryliodide or bromide (1.0 mmol), dimethyl disulfide (1.2 mmol),Cu(OAc)2·H2O (0.1 mmol), KOH (2.0 mmol), TBAB (0.05 mmol),and H2O (2.0 mL). The mixture was stirred at 100 °C (130 °C forbromides) for 12 h under air then cooled to r.t. The mixture wasdiluted with H2O (5 mL) and extracted with EtOAc (4 × 10 mL).The extracts were combined, washed with brine (3 × 10 mL),dried (MgSO4), filtered, and concentrated. The residue was purifiedby chromatography [silica gel, EtOAc–hexane (1:30 to1:100)].
References:
Wang, Ying-Yu;Wu, Xiang-Mei;Yang, Ming-Hua [Synlett,2020] Location in patent:supporting information
624-92-0
314 suppliers
$20.62/5 mL
104-94-9
476 suppliers
$9.00/1g
1879-16-9
118 suppliers
$10.00/1g
3517-99-5
24 suppliers
inquiry
1879-16-9
118 suppliers
$10.00/1g
696-62-8
343 suppliers
$5.00/1g
67-68-5
1217 suppliers
$15.00/100g
1879-16-9
118 suppliers
$10.00/1g
93-58-3
472 suppliers
$13.50/100 mL
696-62-8
343 suppliers
$5.00/1g
1879-16-9
118 suppliers
$10.00/1g