Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
logo
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook

Welcome back!

Structured search
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 1-METHYL-1-(TRIMETHYLSILYL)ALLENE
74542-82-8

1-METHYL-1-(TRIMETHYLSILYL)ALLENE synthesis

7synthesis methods
1-methyl-1-(trialkylsilyl)allenes can be conveniently prepared by the method of Vermeer. Silylsubstituted propargyl mesylates thus undergo SN2 displacement by the organocopper reagent generated from methylmagnesium chloride, copper(I) bromide, and lithium bromide 1-Methyl-1-(trimethylsilyl)allene is produced in 52% yield from commercially available (trimethylsilyl)propargyl alcohol in this fashion (eq 1). The t-butyldimethylsilyl and triisopropylsilyl analogs are synthesized by the same method in 90% and 58% yield, respectively. Propargyl alcohols bearing these and other trialkylsilyl groups can be prepared by treatment of propargyl alcohol with n-butyllithium and the appropriate trialkylsilyl chloride. Allenylsilanes bearing other C-1 substituents can be prepared in an analogous manner by using the appropriate Grignard reagents.

5272-36-6 Synthesis
3-TRIMETHYLSILYL-2-PROPYN-1-OL

5272-36-6
190 suppliers
$6.00/1g

676-58-4 Synthesis
Methylmagnesium chloride

676-58-4
279 suppliers
$15.00/25ml

1-METHYL-1-(TRIMETHYLSILYL)ALLENE

74542-82-8
12 suppliers
inquiry

-

Yield:74542-82-8 83%

Reaction Conditions:

with methanesulfonyl chloride;copper(I) bromide;lithium bromide in tetrahydrofuran at -70 - 25;

References:

Danheiser, Rick L.;Carini, David J.;Kwasigroch, Carrie A. [Journal of Organic Chemistry,1986,vol. 51,# 20,p. 3870 - 3878]

Chlorotrimethylsilane

75-77-4
568 suppliers
$5.04/10

3355-28-0 Synthesis
1-BROMO-2-BUTYNE

3355-28-0
366 suppliers
$6.00/1g

1-METHYL-1-(TRIMETHYLSILYL)ALLENE

74542-82-8
12 suppliers
inquiry

References
2-Propyn-1-ol, 3-(trimethylsilyl)-, 1-methanesulfonate

71321-17-0
0 suppliers
inquiry

676-58-4 Synthesis
Methylmagnesium chloride

676-58-4
279 suppliers
$15.00/25ml

62108-37-6 Synthesis
1-Trimethylsilyl-1-butyne

62108-37-6
53 suppliers
$11.00/100mg

1-METHYL-1-(TRIMETHYLSILYL)ALLENE

74542-82-8
12 suppliers
inquiry

References
2-Propyn-1-ol, 3-(trimethylsilyl)-, 1-methanesulfonate

71321-17-0
0 suppliers
inquiry

676-58-4 Synthesis
Methylmagnesium chloride

676-58-4
279 suppliers
$15.00/25ml

1-METHYL-1-(TRIMETHYLSILYL)ALLENE

74542-82-8
12 suppliers
inquiry

References
5272-36-6 Synthesis
3-TRIMETHYLSILYL-2-PROPYN-1-OL

5272-36-6
190 suppliers
$6.00/1g

1-METHYL-1-(TRIMETHYLSILYL)ALLENE

74542-82-8
12 suppliers
inquiry

References

1-METHYL-1-(TRIMETHYLSILYL)ALLENE Related Search:

1,2-BUTADIENE Allene