ChemicalBook CAS DataBase List 1-METHYL-1H-INDAZOL-6-YLAMINE

1-METHYL-1H-INDAZOL-6-YLAMINE synthesis

4synthesis methods

Product Name:1-METHYL-1H-INDAZOL-6-YLAMINE
CAS Number:74728-65-7
Molecular formula:C8H9N3
Molecular Weight:147.18

6850-23-3
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$52.00/1 g

74728-65-7
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$16.00/100mg

Yield: 99%

Reaction Conditions:

with hydrogen;platinum(IV) oxide in tetrahydrofuran;ethanol under 1551.49 Torr; for 1.5 h;

Steps:

40.B
Step B: Synthesis of 1 -methyl- lH-indazol-6-amine; [0213] A mixture of l-methyl-6-nitro-lH-indazole (0.480 g, 2.71 mmol), platinum oxide (50 mg), ethanol (20 mL), and tetrahydrofuran (5 mL) was shaken under an atmosphere of hydrogen at 30 psi for 1.5 h. The mixture was filtered and the filtrate evaporated to give 1- methyl-lH-indazol-6-amine (0.395 g, 99%) as an off-white solid: ¹H NMR (500 MHz, CDCl₃) δ 7.80 (s, IH), 7.48 (d, J= 8.5 Hz, IH), 6.57 (dd, J= 8.5, 1.8 Hz, IH), 6.53 (s, IH), 3.94 (s, 3H), 3.86 (br s, 2H); ESI MS m/z 148 [M + H]⁺.

References:

Location in patent:Page/Page column 84-85

7597-18-4 Synthesis